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Titolo:
MESODERMAL DEFECT IN LATE-PHASE OF GASTRULATION BY A TARGETED MUTATION OF FOCAL ADHESION KINASE, FAK
Autore:
FURUTA Y; ILIC D; KANAZAWA S; TAKEDA N; YAMAMOTO T; AIZAWA S;
Indirizzi:
KUMAMOTO UNIV,SCH MED,INST MOLEC EMBRYOL & GENET,DEPT MORPHOGENESIS,2-2-1 HONJO KUMAMOTO 860 JAPAN KUMAMOTO UNIV,SCH MED,INST MOLEC EMBRYOL & GENET,DEPT MORPHOGENESIS KUMAMOTO 860 JAPAN UNIV TOKYO,INST MED SCI,DEPT ONCOL,MINATO KU TOKYO 108 JAPAN
Titolo Testata:
Oncogene
fascicolo: 10, volume: 11, anno: 1995,
pagine: 1989 - 1995
SICI:
0950-9232(1995)11:10<1989:MDILOG>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE KINASE; EXTRACELLULAR-MATRIX; TUMOR-SUPPRESSOR; CELL-ADHESION; MOUSE EMBRYOS; GENE; EXPRESSION; FIBRONECTIN; BETA-1-INTEGRINS; PHOSPHORYLATION;
Keywords:
MUTANT MOUSE; FAK; FOCAL ADHESION; CELL MOBILITY; MESODERM; CELL-EXTRACELLULAR MATRIX INTERACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
Y. Furuta et al., "MESODERMAL DEFECT IN LATE-PHASE OF GASTRULATION BY A TARGETED MUTATION OF FOCAL ADHESION KINASE, FAK", Oncogene, 11(10), 1995, pp. 1989-1995

Abstract

FAK is a unique non-receptor protein tyrosine kinase that was found in cellular focal adhesions. An increasing number of in vitro observations has suggested that FAK mediates signaling through integrins brought about by interactions with extracellular matrix (ECM). It is highly tyrosine-phosphorylated in v-src-transformed cells and during embryogenesis. To clarify the function of FAK in cell-ECM interactions, embryonic phenotype of its mutant was analysed. FAK-deficient embryos could implant and initiate gastrulation normally, but showed abnormalities in. subsequent development. The abnormalities were characterized as a general deficiency in mesoderm, and the phenotype was quite similar to that caused by fibronectin-deficiency. The results suggest that FAK mediates fibronectin-integrin interactions uniquely at this stage of development, thereby playing an essential role in development of mesodermal cell lineages.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 06:24:16