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Titolo:
ACTIVATION OF HUMAN EPIDERMAL LANGERHANS CELLS BY ENGAGEMENT OF THE HIGH-AFFINITY RECEPTOR FOR IGE, FC-EPSILON-RI
Autore:
JURGENS M; WOLLENBERG A; HANAU D; DELASALLE H; BIEBER T;
Indirizzi:
UNIV MUNICH,DEPT DERMATOL,FRAUENLOBSTR 9 D-80337 MUNICH GERMANY UNIV MUNICH,DEPT DERMATOL D-80337 MUNICH GERMANY REG INST BLOOD TRANSFUS,HISTOPATIBIL LAB STRASBOURG FRANCE
Titolo Testata:
The Journal of immunology
fascicolo: 11, volume: 155, anno: 1995,
pagine: 5184 - 5189
SICI:
0022-1767(1995)155:11<5184:AOHELC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOGLOBULIN-E; ATOPIC-DERMATITIS; TYROSINE PHOSPHORYLATION; CYTOPLASMIC DOMAINS; TRANSFECTED CELLS; BETA-SUBUNIT; PROTEIN; GAMMA; INTERNALIZATION; ANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
M. Jurgens et al., "ACTIVATION OF HUMAN EPIDERMAL LANGERHANS CELLS BY ENGAGEMENT OF THE HIGH-AFFINITY RECEPTOR FOR IGE, FC-EPSILON-RI", The Journal of immunology, 155(11), 1995, pp. 5184-5189

Abstract

Human epidermal Langerhans cells (LCs) bind IgE via the high affinityreceptor (Fc epsilon RI), and therefore are suspected to be involved in the genesis of atopic diseases. In this study, we report that surface expression of Fc epsilon RI is increased dramatically on LCs from patients with atopic dermatitis (AD) when compared with nonatopic individuals, Cross-linking of Fc epsilon RI on LCs from nonatopic individuals and patients with AD leads to a rapid tyrosine phosphorylation of several proteins, including p72, p77, and p95. However, upon receptor ligation, calcium mobilization is only detected in LCs freshly isolatedfrom patients with AD (responder LCs), but not in those from normal skin of healthy individuals (nonresponder LCs), The beta-chain of Fc epsilon RI is not detected in normal LCs and only in a minority of LCs from atopic individuals, indicating that it is not related to the capacity of LCs to respond to Fc epsilon RI-mediated activation, In contrast, LCs from both nonatopic and atopic individuals internalize Fc epsilon RI by receptor-mediated endocytosis as a prerequisite for Ag focusing. Therefore, LCs from normal individuals and individuals with AD differ functionally by their Fc epsilon RI expression and by a distinct ability to respond to Fc epsilon RI-mediated activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:23:03