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Titolo:
ASSESSMENT OF MYOCARDIAL PERFUSION AND VIABILITY WITH TC-99M METHOXYISOBUTYLISONITRILE AND TL-201 REST REDISTRIBUTION IN CHRONIC CORONARY-ARTERY DISEASE
Autore:
ROSSETTI C; LANDONI C; LUCIGNANI G; HUANG G; BARTORELLI AL; GUAZZI MD; MARGONATO A; CHIERCHIA S; GALLI L; SAVI A; FAZIO F;
Indirizzi:
INST H SAN RAFFAELE,DEPT NUCL MED,VIA OLGETTINA 60 I-20132 MILAN ITALY UNIV MILAN,INST H SAN RAFFAELE,INB,CNR MILAN ITALY UNIV MILAN,INST CARDIOL,CNR,I MONZINO FDN MILAN ITALY
Titolo Testata:
European journal of nuclear medicine
fascicolo: 11, volume: 22, anno: 1995,
pagine: 1306 - 1312
SICI:
0340-6997(1995)22:11<1306:AOMPAV>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; METHOXY ISOBUTYL ISONITRILE; ASSESSING VIABLE MYOCARDIUM; METABOLIC-ACTIVITY; TL-201; SCINTIGRAPHY; REINJECTION; IDENTIFICATION; EXERCISE; PLANAR;
Keywords:
SINGLE-PHOTON EMISSION TOMOGRAPHY; POSITRON EMISSION TOMOGRAPHY; MYOCARDIAL PERFUSION; MYOCARDIAL VIABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
C. Rossetti et al., "ASSESSMENT OF MYOCARDIAL PERFUSION AND VIABILITY WITH TC-99M METHOXYISOBUTYLISONITRILE AND TL-201 REST REDISTRIBUTION IN CHRONIC CORONARY-ARTERY DISEASE", European journal of nuclear medicine, 22(11), 1995, pp. 1306-1312

Abstract

We compare thallium-201 rest redistribution and fluorine-18 fluorodeoxyglucose ([F-18]FDG) for the assessment of myocardial viability within technetium 99m methoxyisobutylisonitrile (MIBI) perfusion defects in27 patients with chronic stable coronary artery disease. The following studies were performed: (1) stress Tc-99m-MIBI, (2) rest Tc-99m-MIBI, (3) Tl-201 rest-redistribution single-photon emission tomography, (4) [F-18]FDG positron emission tomography. The left ventricle was devided into II segments on matched tomographic images, The segment with the highest activity at stress was taken as the reference (activity=100%). Perfusion defects at Tc-99m-MIBI rest were classified as severe (activity <50%), moderate (activity 50%-60%) or mild (activity 60%-85%). Uptakes of [F-18]FDG and rest-redistributed Tl-201 were recognized as significant if they exceeded 50% of that in the reference segment. Among the 33 segments with severe Tc-99m-MIBI rest perfusion defects, 21 had significant [F-18]FDG and 10 significant rest-redistributed Tl-201uptake. As regards the 37 segments with moderate defects, [F-18]FDG was present in 29 and Tl-201 in 31, while of the 134 segments with milddefects, 128 showed [F-18]FDG uptake, and 131, Tl-201 uptake. In conclusion, there is an inverse relationship between the severity of Tc-99m-MIBI perfusion defects and the uptake of rest-redistributed Tl-201 and [F-18]FDG. Both tracers are adequate markers of viability in mild and moderate defects; in severe defects Tl-201 might underestimate the presence of viability as assessed by [F-18]FDG.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 21:26:21