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Titolo:
CONFIRMATION OF BENZODIAZEPINES IN URINE AS TRIMETHYLSILYL DERIVATIVES USING GAS-CHROMATOGRAPHY MASS-SPECTROMETRY
Autore:
MOORE C; LONG G; MARR M;
Indirizzi:
UNITED CHEM TECHNOL,2731 BARTRAM RD BRISTOL PA 19007 UNITED CHEM TECHNOL BRISTOL PA 19007
Titolo Testata:
Journal of chromatography B. Biomedical applications
fascicolo: 1, volume: 655, anno: 1994,
pagine: 132 - 137
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIQUID-CHROMATOGRAPHY; ABBOTT ADX; SERUM; ALPRAZOLAM; CLONAZEPAM; QUANTIFICATION; EXTRACTION; PLASMA; HPLC;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
C. Moore et al., "CONFIRMATION OF BENZODIAZEPINES IN URINE AS TRIMETHYLSILYL DERIVATIVES USING GAS-CHROMATOGRAPHY MASS-SPECTROMETRY", Journal of chromatography B. Biomedical applications, 655(1), 1994, pp. 132-137

Abstract

A confirmation procedure for the identification and quantitation of various benzodiazepines in urine is presented. The urine sample is first hydrolyzed enzymatically because of the glucuronide conjugation of some benzodiazepine metabolites, then extracted using bonded-phase columns. After elution into an organic solvent, the samples are evaporated, converted to the trimethylsilyl ether derivatives and analyzed by electron ionization GC-MS. Quantitation was performed using selected-ionmonitoring for each benzodiazepine using prazepam as the internal standard. The method provides excellent linearity and sensitivity for thetrimethylsilyl derivatives.

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Documento generato il 24/11/20 alle ore 14:03:05