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Titolo:
INTRACOLONIC RELEASE IN-VIVO OF INTERLEUKIN-1-BETA IN CHRONIC ULCERATIVE-COLITIS
Autore:
CASELLAS F; PAPO M; GUARNER F; ANTOLIN M; SEGURA RM; ARMENGOL JR; MALAGELADA JR;
Indirizzi:
HOSP GEN VALLE HEBRON,DIGEST SYST RES UNIT,PSO VALL DHEBRON 119 E-08035 BARCELONA SPAIN
Titolo Testata:
Clinical science
fascicolo: 5, volume: 89, anno: 1995,
pagine: 521 - 526
SICI:
0143-5221(1995)89:5<521:IRIOII>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY BOWEL-DISEASE; CROHNS-DISEASE; RECEPTOR ANTAGONIST; ENHANCED PRODUCTION; IL-1 RECEPTOR; INHIBITOR; RATS;
Keywords:
COLONIC PERFUSION; EICOSANOIDS; INTERLEUKIN-L-BETA; ULCERATIVE COLITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
F. Casellas et al., "INTRACOLONIC RELEASE IN-VIVO OF INTERLEUKIN-1-BETA IN CHRONIC ULCERATIVE-COLITIS", Clinical science, 89(5), 1995, pp. 521-526

Abstract

1. To investigate the role of interleukin-1 beta in chronic ulcerative colitis, we quantified interleukin-1 beta steady-state release into the colonic lumen. 2. We studied 26 paients with untreated chronic ulcerative colitis and seven patients with irritable bowel syndrome who served as disease controls, In seven ulcerative colitis patients, the disease was inactive and in 19 it was mild to moderately active, according to clinical and colonoscopic criteria. Seven patients with active colitis were studied before and after 4 weeks of treatment with oral 5-aminosalicylic acid. 3. Colonic perfusions were performed using a double-lumen technique, An isotonic solution was continuously infused 50 cm from the anal verge at 5 ml/min, and was recovered 30 cm distally by siphonage, Interleukin-1 beta was measured by ELISA, polymorphonuclear elastase by immunoactivation and leukotriene B-4 by specific RIA. 4. All control patients and five out of seven patients with inactive colitis had undetectable interleukin-1 beta release. In active colitis, the release of interleukin-1 beta was detected in 17 out of 19 patients (median 500 pg/min, interquartiles 270-1582 pg/min, P<0.01 compared with control subjects and patients with inactive colitis), Elastase and leukotriene B, release were also significantly increased in active colitis compared with inactive colitis and controls, Leukotriene B, release was similar in inactive colitis and controls, whereas elastase release was higher in inactive colitis than in control. Five out of seven patients with colitis improved after treatment with 5-aminosalicylicacid, In all responder patients, interleukin-1 beta became undetectable or declined. 5. Our results demonstrate under conditions in vivo that active colitis is associated with enhanced interleukin-1 beta release into the colonic lumen whereas such release does not occur in remission, supporting the concept that ulcerative colitis flare-ups involveincreased interleukin-1 beta production.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:14:43