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Titolo:
EVALUATION OF THE EFFECTS OF HYDRALAZINE ON LIPID-PEROXIDATION AND ATHEROGENESIS
Autore:
KAMSIAH J; NAFEEZA MI; VASUDEVAN SK;
Indirizzi:
UNIV KEBANGSAAN MALAYSIA,FAC MED,DEPT PHARMACOL KUALA LUMPUR 50300 MALAYSIA
Titolo Testata:
Asia Pacific journal of pharmacology
fascicolo: 2, volume: 10, anno: 1995,
pagine: 59 - 63
SICI:
0217-9687(1995)10:2<59:EOTEOH>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Keywords:
HYDRALAZINE; LIPID PEROXIDATION; HIGH CHOLESTEROL DIET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
J. Kamsiah et al., "EVALUATION OF THE EFFECTS OF HYDRALAZINE ON LIPID-PEROXIDATION AND ATHEROGENESIS", Asia Pacific journal of pharmacology, 10(2), 1995, pp. 59-63

Abstract

We studied the possible effects of hydralazine on lipid peroxidation and atherogenesis in sixteen male rabbits given a 2% cholesterol diet. Of these, eight were given intramuscular injections of hydralazine 1.25 mg kg(-1) body weight twice daily for 10 weeks while the remaining eight served as controls. The serum malondialdehyde (MDA) and diene were significantly higher in the hydralazine group compared to the control group (P<0.05). The Sudan IV positive intimal lesion, aortic tissuecholesterol, diene and MDA content were also significantly higher in the hydralazine group (P<0.05). The increase in lipid peroxidation andatherogenesis suggest hydralazine as a possible oxidant.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:29:17