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Titolo:
EFFECTS OF (-AMPHETAMINE ON MOTOR-NERVE TERMINALS OF MOUSE SKELETAL-MUSCLE())
Autore:
TSAI MC; HO CC; CHEN YH;
Indirizzi:
NATL TAIWAN UNIV,COLL MED,DEPT PHARMACOL TAIPEI 10764 TAIWAN
Titolo Testata:
Asia Pacific journal of pharmacology
fascicolo: 2, volume: 10, anno: 1995,
pagine: 53 - 58
SICI:
0217-9687(1995)10:2<53:EO(OMT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Keywords:
AMPHETAMINE; NERVE TERMINAL CURRENT; PSYCHOTROPIC DRUG; NEUROMUSCULAR TRANSMISSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
M.C. Tsai et al., "EFFECTS OF (-AMPHETAMINE ON MOTOR-NERVE TERMINALS OF MOUSE SKELETAL-MUSCLE())", Asia Pacific journal of pharmacology, 10(2), 1995, pp. 53-58

Abstract

The effects of (+)-amphetamine, a psychotropic drug, on motor nerve terminal activity were assessed on mouse triangularis sterni nerve-muscle preparations. The perineural waveforms were recorded with extracellular electrodes placed in the perineural sheaths of motor nerves. (+)-Amphetamine (13.6 mu M) decreased the components of waveform associated with potassium current and the slow potassium current of nerve terminal, while it had no effect on that associated with the sodium, calcium and the calcium activated potassium currents of the nerve terminal. (+)-Amphetamine also increased the frequency of spontaneously generated MEPPs and the quantal content of EPP. However, (+)-amphetamine decreased the amplitude of EPP. The MEPP was diminished in amplitude to theextent that the EPP was reduced despite an increase in quantal content. It is concluded that amphetamine decreased the potassium current inthe nerve terminal. The effect may contribute to its pharmacological actions on synaptic transmission.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 17:17:22