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Titolo:
ANALYSIS OF FETAL AND NEONATAL URINE USING PROTON NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY
Autore:
FOXALL PJD; BEWLEY S; NEILD GH; RODECK CH; NICHOLSON JK;
Indirizzi:
UNIV LONDON BIRKBECK COLL,DEPT CHEM,29 GORDON SQ LONDON WC1H 0PP ENGLAND UNIV COLL LONDON,DEPT OBSTET & GYNAECOL LONDON ENGLAND UNIV COLL LONDON,INST UROL & NEPHROL LONDON ENGLAND
Titolo Testata:
Archives of Disease in Childhood
fascicolo: 3, volume: 73, anno: 1995,
pagine: 153 - 157
SICI:
0003-9888(1995)73:3<153:AOFANU>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVE ORGANIC SOLUTES; RENAL INNER MEDULLA; OBSTRUCTIVE UROPATHY; NMR-SPECTROSCOPY; INBORN-ERRORS; METABOLISM; DISEASE; FLUIDS; PLASMA; RAT;
Keywords:
H-1 NMR SPECTROSCOPY; URINALYSIS; FETAL OBSTRUCTIVE UROPATHY; OSMOLYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
P.J.D. Foxall et al., "ANALYSIS OF FETAL AND NEONATAL URINE USING PROTON NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY", Archives of Disease in Childhood, 73(3), 1995, pp. 153-157

Abstract

.Aim-To use high field proton nuclear magnetic resonance spectroscopy(H-1 NMR) to characterise the low molecular weight metabolite composition of neonatal and fetal urine in relation to gestational age and perinatal outcome. Methods-The first urine passed by two neonatal groups, six full term and five preterm infants with normal renal function, was analysed by 1H NMR and compared with fetal urine from 14 cases withobstructive uropathy. Results-The mean ratios of taurine, myo-inositol, and trimethylamine-N-oxide (TMAO) to creatinine were 4.3, 10.1, and14.1 times higher, respectively, in the preterm group when compared with those of the full term group. Fetal obstructive uropathy was characterised by glycosuria, amino and organic aciduria, regardless of gestational age (13-30 weeks). Conclusions-Samples of the first urine passed - that is, urine produced in fetal life - by normal preterm infantsare useful controls for cases of obstructive uropathy detected in thethird timester. H-1 NMR will become a clinically useful tool for monitoring renal development and abnormalities in utero.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 07:31:48