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Titolo:
ENANTIOSELECTIVE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ASSAY FOR DETERMINATION OF THE ENANTIOMERS OF A NEW ANTIULCER AGENT, E3810, IN BEAGLE DOG PLASMA AND RAT PLASMA
Autore:
TAKAKUWA S; CHIKU S; NAKATA H; YUZURIHA T; MANO N; ASAKAWA N;
Indirizzi:
EISAI & CO LTD,TSUKUBA RES LABS,DRUG METAB & PHARMACOKINET SECT,5-1-3TOKODAI TSUKUBA IBARAKI 30026 JAPAN EISAI & CO LTD,TSUKUBA RES LABS,PHYS & ANALYT CHEM SECT TSUKUBA IBARAKI 30026 JAPAN
Titolo Testata:
Journal of chromatography B. Biomedical applications
fascicolo: 1, volume: 673, anno: 1995,
pagine: 113 - 122
Fonte:
ISI
Lingua:
ENG
Soggetto:
OMEPRAZOLE; INHIBITOR; SECRETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
S. Takakuwa et al., "ENANTIOSELECTIVE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ASSAY FOR DETERMINATION OF THE ENANTIOMERS OF A NEW ANTIULCER AGENT, E3810, IN BEAGLE DOG PLASMA AND RAT PLASMA", Journal of chromatography B. Biomedical applications, 673(1), 1995, pp. 113-122

Abstract

An enantioselective high-performance liquid chromatographic method for the determination of E3810, a new anti-ulcer agent, in Beagle dog plasma and rat plasma has been developed. After extraction from plasma with ethyl acetate, E3810 enantiomers were measured by reversed-phase high-performance liquid chromatography on a Chiralcel OD-R column. The enantiomers were detected by ultraviolet absorbance detection at 290 nm. The recoveries of E3810 enantiomers and internal standard were greater than 91%. The calibration curves were linear from 0.03 to 20 mu g/ml for Beagle dog plasma and from 0.1 to 100 mu g/ml for rat plasma. The limits of quantification of both enantiomers were 0.03 mu g/ml for Beagle dog plasma and 0.1 mu g/ml for rat plasma. The intra- and inter-day accuracy and precision data showed good reproducibility of the method. The assay was applied for the analysis of E3810 enantiomers in plasma after intravenous administration of racemic E3810 to Beagle dogsand rats. This method should be very useful for enantioselective pharmacokinetic studies of E3810.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:04:40