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Titolo:
VOLUMETRIC BONE-MINERAL DENSITY - A POTENTIAL ROLE IN PEDIATRICS
Autore:
COWELL CT; LU PW; LLOYDJONES SA; BRIODY JN; ALLEN JR; HUMPHRIES IRJ; REED E; KNIGHT J; HOWMANGILES R; GASKIN K;
Indirizzi:
ROYAL ALEXANDRA HOSP CHILDREN,DEPT ENDOCRINOL,POB 34 CAMPERDOWN NSW 2050 AUSTRALIA ROYAL ALEXANDRA HOSP CHILDREN,ROBERT VINES GROWTH RES CTR SYDNEY NSW AUSTRALIA ROYAL ALEXANDRA HOSP CHILDREN,JAMES FAIRFAX INST NUTR SYDNEY NSW AUSTRALIA ROYAL ALEXANDRA HOSP CHILDREN,DEPT NUCL MED SYDNEY NSW AUSTRALIA ROYAL ALEXANDRA HOSP CHILDREN,DEPT RENAL MED SYDNEY NSW AUSTRALIA
Titolo Testata:
Acta paediatrica
, volume: 84, anno: 1995, supplemento:, 411
pagine: 12 - 17
SICI:
0803-5253(1995)84:<12:VBD-AP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHALED BECLOMETHASONE DIPROPIONATE; RENAL-FAILURE; LUMBAR SPINE; CHILDREN; METABOLISM; STAGE; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
C.T. Cowell et al., "VOLUMETRIC BONE-MINERAL DENSITY - A POTENTIAL ROLE IN PEDIATRICS", Acta paediatrica, 84, 1995, pp. 12-17

Abstract

The use of areal bone mineral density (aBMD) in paediatric populations has aroused some concern, as it fails to take the age-related increase in bone thickness into account. We have developed a measure of truebone density, volumetric bone mineral density (vBMD), which is independent of age and height. In order to examine the relationship between growth parameters, aBMD and vBMD, we studied patients with phenylketonuria (PKU, n = 40), chronic renal failure (CRF, n = 27) and chronic asthma (n = 19). aBMD of the femoral neck and the mid-femoral shaft was measured using dual energy X-ray absorptiometry (DXA), vBMD was calculated on the basis of values of bone mineral content and bone dimensionprovided by DXA, with the assumption that both sites are cylinders. aBMD and vBMD were then compared with the normal reference, expressed as a standard deviation score (SDS). aBMD and vBMD were normal in the femoral neck region of the PKU group, but aBMD, either standardized forage or for height, was low in the femoral shaft region (p < 0.01). Inthe CRF group, profound growth retardation was seen (mean height SDS,-3.2) and aBMD and vBMD were both low in the femoral shaft region butnot in the femoral neck. In the asthma group, aBMD for age was low atboth sites, but vBMD did not differ from that seen in normal individuals. We conclude that the true vBMD provides a different interpretation of bone density compared with aBMD and requires further evaluation in paediatrics because of its age and height independence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:00:00