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Titolo:
EFFECTS OF MALIGNANCY AND INTERLEUKIN-2 INFUSION ON GUT MACROMOLECULAR PERMEABILITY
Autore:
RYAN CM; ATKINS MB; MIER JW; GELFAND JA; TOMPKINS RG;
Indirizzi:
MASSACHUSETTS GEN HOSP,SURG SERV BOSTON MA 02114 MASSACHUSETTS GEN HOSP,SURG SERV BOSTON MA 02114 HARVARD UNIV,SCH MED,DEPT SURG BOSTON MA 02115 TUFTS UNIV NEW ENGLAND MED CTR,DEPT MED BOSTON MA 02111 TUFTS UNIV,SCH MED BOSTON MA 02111
Titolo Testata:
Critical care medicine
fascicolo: 11, volume: 23, anno: 1995,
pagine: 1801 - 1806
SICI:
0090-3493(1995)23:11<1801:EOMAII>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTESTINAL PERMEABILITY; NITRIC-OXIDE; RECEPTOR LEVELS; IL-2 RECEPTOR; CANCER; INJURY; IMMUNOTHERAPY; ABSORPTION; INTEGRITY; THERAPY;
Keywords:
PERMEABILITY, GUT; INTERLEUKIN-2; POLYETHYLENE GLYCOL; MELANOMA; INFLAMMATION; SHOCK; CYTOKINES; CARCINOMA, RENAL CELL; CRITICAL ILLNESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
C.M. Ryan et al., "EFFECTS OF MALIGNANCY AND INTERLEUKIN-2 INFUSION ON GUT MACROMOLECULAR PERMEABILITY", Critical care medicine, 23(11), 1995, pp. 1801-1806

Abstract

Objective: Enhanced gut permeability has been shown in patients with advanced malignancy, The dramatic inflammatory shock syndrome producedby high-dose interleukin-a immune therapy could further change gut barrier function, This study measured the effect of advanced renal cell carcinoma and malignant melanoma, and interleukin-2 treatment on gut permeability, Design: Nonrandomized, controlled study, Setting: University hospital, Patients: Adults with metastatic, unresectable renal cell carcinoma or metastatic, malignant melanoma, and normal volunteers, Interventions: Gut permeability was measured in patients with renal cell carcinoma or malignant melanoma before and during interleukin-a infusions, using polyethylene glycol 3350 and polyethylene glycol 400. The polyethylene glycols were administered orally within 48 hrs of interleukin-a therapy and the 24-hr urine excretions were measured. Measurements and Main Results: Increased permeability was seen in the baseline state of these patients (ratio of polyethylene glycol 3350 to polyethylene glycol 400 = 1.1 +/- 0.7 x 10(-2)) when compared with normal volunteers (ratio = 0.48 +/- 0.2 x 10(-2); p < .05), However, after interleukin-a treatment, no further increase in permeability was seem (ratio = 1.4 +/- 0.8 x 10(-2)). Conclusions: Gut permeability to polyethylene glycol 3350 is enhanced in advanced malignancy. High-dose interleukin-2 therapy does not further increase permeability of the gut.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 05:48:27