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Titolo:
THE APPLICATION OF BLOOD-FLOW MEASUREMENTS TO THE STUDY OF AGING MUSCLE
Autore:
MCCULLY KK; POSNER JD;
Indirizzi:
MED COLL PENN,DIV GERIATR & REHABIL MED,3300 HENRY AVE PHILADELPHIA PA 19129 HAHNEMANN UNIV PHILADELPHIA PA 19129
Titolo Testata:
The journals of gerontology. Series A, Biological sciences and medical sciences
, volume: 50, anno: 1995,
pagine: 130 - 136
SICI:
1079-5006(1995)50:<130:TAOBMT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; PERIPHERAL VASCULAR-DISEASE; NEAR-INFRARED SPECTROSCOPY; SKELETAL-MUSCLE; MR-ANGIOGRAPHY; PRESSURE INDEX; SPIN INVERSION; ARTERIAL WATER; HEART-FAILURE; ELDERLY MEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
80
Recensione:
Indirizzi per estratti:
Citazione:
K.K. Mccully e J.D. Posner, "THE APPLICATION OF BLOOD-FLOW MEASUREMENTS TO THE STUDY OF AGING MUSCLE", The journals of gerontology. Series A, Biological sciences and medical sciences, 50, 1995, pp. 130-136

Abstract

Blood flow to skeletal muscle is a potentially important factor the reduction of muscle function associated with aging (sarcopenia). The main influence of reduced blood flow capacity on muscle function is in limiting oxidative metabolism. Direct measures of blood flow include: intraviral-microscopy, plethysmography, radioactive microspheres, (133)Xenon washout, thermodilution, and Doppler ultrasound Indirect measurement of bloodflow includes arm-to-ankle pressure index and the rate ofphosphocreatine recovery after exercise. Several new methodologies have been developed to evaluate muscle blood flow, including color-Doppler imaging, magnetic resonance imaging/ angiography (MRI/MRA), and near-infrared spectroscopy (NIRS). As adaptations of traditional techniques, these methods promise more precise information under less invasiveconditions. MRI is an expensive and technically challenging method able to measure vessel location, bloodflow, and wall diameter in blood vessels throughout the cardiac cycle. Color-Doppler provides excellent temporal resolution blood flow throughout the cardiac cycle, along with some anatomical information. NIRS is an inexpensive and portable technology that can measure changes in oxygen saturation curd provide information on tissue oxygen delivery in studies of frailer and more difficult-to-study subjects. Muscle blood flow is not thought to limit oxidative metabolism under normal conditions in young individuals. However, if is not clear what happens to mascle blood flow in healthy older individuals. Reduced capillary density, less maximal blood flow, and aslower hyperemic flow response have been reported in same, but not all, studies, Further studies with the newer methodologies are needed tore-examine age-related changes in muscle blood flow. Small reductionsin muscle bloodflow may not be noticed in older individuals, althoughthis has not been thoroughly studied. Once again, more studies are needed to better understand the relationship between reduced blood flow and muscle function in the elderly.

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Documento generato il 18/09/20 alle ore 16:04:46