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Titolo:
OUTCOME OF BURKHOLDERIA (PSEUDOMONAS) CEPACIA COLONIZATION IN CHILDREN WITH CYSTIC-FIBROSIS FOLLOWING A HOSPITAL OUTBREAK
Autore:
WHITEFORD ML; WILKINSON JD; MCCOLL JH; CONLON FM; MICHIE JR; EVANS TJ; PATON JY;
Indirizzi:
UNIV GLASGOW,YORKHILL NHS TRUST,DEPT CHILD HLTH GLASGOW G3 8SJ LANARKSCOTLAND UNIV GLASGOW,YORKHILL NHS TRUST,DEPT CHILD HLTH GLASGOW G3 8SJ LANARKSCOTLAND UNIV GLASGOW,DEPT STAT GLASGOW G12 8QQ LANARK SCOTLAND
Titolo Testata:
Thorax
fascicolo: 11, volume: 50, anno: 1995,
pagine: 1194 - 1198
SICI:
0040-6376(1995)50:11<1194:OOB(CC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY INFECTION; COLONIZATION; TRANSMISSION;
Keywords:
CYSTIC FIBROSIS; CHILDREN; BURKHOLDERIA (PSEUDOMONAS) CEPACIA; LUNG FUNCTION; CROSS INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
M.L. Whiteford et al., "OUTCOME OF BURKHOLDERIA (PSEUDOMONAS) CEPACIA COLONIZATION IN CHILDREN WITH CYSTIC-FIBROSIS FOLLOWING A HOSPITAL OUTBREAK", Thorax, 50(11), 1995, pp. 1194-1198

Abstract

Background - While there are reports on the outcome in adults and teenagers with cystic fibrosis of colonisation with Burkholderia (Pseudomonas) cepacia, there is little information in children. Methods - In December 1991 only one of 115 children with cystic fibrosis attending apaediatric centre was colonised with B cepacia. Over the next 12 months there was a rapid increase with 23 (20%) becoming colonised; eighteen (79%) of these became colonised in hospital at a time that overlapped with the admission of a B cepacia positive child. Three different bacteriocin types were isolated, with one type (S22/PO) being present in 17 (74%) patients. The outcome for children who became colonised with B cepacia was compared with that in 33 children who continued to be colonised with Pseudomonas aeruginosa alone. Results - Children colonised with B cepacia were older and more poorly nourished than those colonised with P aeruginosa, but did not have poorer pulmonary function. After colonisation, the forced expiratory volume in one second (FEV,) deteriorated between consecutive annual tests, with the average deterioration being greater in those with higher initial levels. Five children with B cepacia died from respiratory failure although none showed afulminant deterioration. Introduction of segregation measures within hospital led to a dramatic decrease in the number of newly colonised patients. Conclusions - This study provides further evidence for person-to-person spread of B cepacia and confirms the effectiveness of simple isolation measures in interrupting spread. Colonisation with B cepacia and P aeruginosa in children is associated with a more rapid decline in lung function and a significantly increased mortality compared with cases colonised with P aeruginosa alone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 18:28:57