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Titolo:
DOPAMINERGIC AND GLUTAMATERGIC MECHANISMS MEDIATE THE INDUCTION OF FOS-LIKE PROTEIN BY COCAETHYLENE
Autore:
HOROWITZ JM; DIPIRRO JM; KRISTAL MB; TORRES G;
Indirizzi:
SUNY BUFFALO,DEPT PSYCHOL,BEHAV NEUROSCI PROGRAM BUFFALO NY 14260 SUNY BUFFALO,DEPT PSYCHOL,BEHAV NEUROSCI PROGRAM BUFFALO NY 14260
Titolo Testata:
Brain research bulletin
fascicolo: 5, volume: 42, anno: 1997,
pagine: 393 - 398
SICI:
0361-9230(1997)42:5<393:DAGMMT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRIATAL C-FOS; COCAINE-ETHANOL INGESTION; MESSENGER-RNA EXPRESSION; EARLY GENE-EXPRESSION; LOCOMOTOR-ACTIVITY; RAT STRIATUM; RECEPTORS; TRANSCRIPTION; PHARMACOLOGY; METABOLITE;
Keywords:
COCAINE; DOPAMINE; D-1 RECEPTOR; DYNORPHIN; ETHANOL; LOCOMOTOR ACTIVITY; NMDA RECEPTOR; RAT; SEROTONIN; SPIRADOLINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Horowitz et al., "DOPAMINERGIC AND GLUTAMATERGIC MECHANISMS MEDIATE THE INDUCTION OF FOS-LIKE PROTEIN BY COCAETHYLENE", Brain research bulletin, 42(5), 1997, pp. 393-398

Abstract

Cocaethylene is a psychoactive metabolite formed during the combined consumption of cocaine and ethanol. As this metabolite has many properties in common with cocaine, it is conceivable that cocaethylene administration may induce the activity of nuclear transcription factors that regulate the expression of late-response genes. Therefore, the temporal induction of FOS-like protein in rat brain was examined following IP administration of 60 mu mol/kg cocaethylene. Immunoreactivity for the protein was detectable at 1 h in striatal neurons and had virtuallydisappeared 6 h after drug treatment. Administration of specific dopaminergic (SCH-23390; 0.5 mg/kg) and glutamatergic (MK-801; 1 mg/kg) receptor antagonists prior to cocaethylene indicated a significant role for dopamine (D-1) and N-methyl-D-aspartate receptor subtypes in mediating the nuclear induction of the aforementioned transcription factor protein. In contrast, no significant effects on FOS-like protein in discrete neurons of the caudate putamen were found when spiradoline (U-62066), a kappa opioid-receptor agonist, was administered either IP (10mg/kg) or directly (50 nmol) into the brain parenchyma. In addition, we uncovered a differential sensitivity of Long-Evans rats to the behavioral effects of cocaethylene, with the psychoactive metabolite producing significantly less behavioral activity (e.g., locomotion, rearing, and continuous sniffing) than that produced by cocaine (molar equivalent of 60 mu mol/kg cocaethylene). These findings indicate both common and disparate effects of cocaethylene and its parent compound, cocaine, on receptor pathways that regulate target alterations in gene expression and drug-induced motor behavior. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 03:07:36