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Titolo:
TUBERCULIN SKIN-TEST AND CD4+ CD8+ T-CELL COUNTS IN ADULTS INFECTED WITH THE HUMAN-IMMUNODEFICIENCY-VIRUS IN MEDELLIN, COLOMBIA/
Autore:
RODRIGUEZ JI; ARIAS M; PARIS SC; ARBELAEZ MP; BETANCUR J; GARCIA LF;
Indirizzi:
UNIV ANTIOQUIA,FAC NACL SALUD PUBL,LAB CENT INVEST MEDELLIN COLOMBIA UNIV ANTIOQUIA,FAC NACL SALUD PUBL,LAB CENT INVEST MEDELLIN COLOMBIA UNIV ANTIOQUIA,DEPT MED INTERNA MEDELLIN COLOMBIA
Titolo Testata:
Memorias do Instituto Oswaldo Cruz
fascicolo: 2, volume: 92, anno: 1997,
pagine: 245 - 250
SICI:
0074-0276(1997)92:2<245:TSACCT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVENOUS-DRUG-USERS; HIV-INFECTION; ANERGY; PATTERNS; AIDS;
Keywords:
HIV; TUBERCULIN; BCG VACCINATION; CD4; CD8;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
J.I. Rodriguez et al., "TUBERCULIN SKIN-TEST AND CD4+ CD8+ T-CELL COUNTS IN ADULTS INFECTED WITH THE HUMAN-IMMUNODEFICIENCY-VIRUS IN MEDELLIN, COLOMBIA/", Memorias do Instituto Oswaldo Cruz, 92(2), 1997, pp. 245-250

Abstract

To evaluate the effect of BCG vaccination and T lymphocyte subpopulations on the reactivity to the tuberculin skin test, 113 asymtomatic HIV+ individuals were tuberculin tested by intradermal injection of 5TU of purified protein derivative and the levels of circulating lymphocyte (CD3, CD4 and CD8) subpopulations determined by indirect immunofluorescence. Ninety-two percent of the subjects included in the study weremales. The mean age of the group was 32.1 +/- 7.4 years. Sixty-two percent presented a BCG scar: However, only 22% exhibited positive tuberculin reactions (greater than or equal to 5 mm) irrespective of the presence of the BCG scar: Tuberculin positive individuals exhibited higher CD4+ cell counts (p = 0.004) and CD4+/CD8+ ratios (p = 0.006) than tuberculin negative (< 5 mm) HIV+ individuals. The number of individuals with positive tuberculin reactions was significantly higher in subjects with more than 500 CD4+ lymphocytes/mu l (p = 0.02) or CD4+/CD8+ ratios greater than or equal to 1.12 (p = 0.002). These results suggest that a prior BCG vaccination does not influence the reactivity to the tuberculin skin test in HIV+ asymptomatic individuals and that the number of CD4+ lymphocytes and the CD4+/CD8+ ratio positively correlatewith the tuberculin reactivity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 16:08:57