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Titolo:
FUNCTIONAL-ROLE OF MICROVASCULAR INTEGRITY IN PATIENTS WITH INFARCT-RELATED ARTERY PATENCY AFTER ACUTE MYOCARDIAL-INFARCTION
Autore:
ILICETO S; GALIUTO L; MARCHESE A; COLONNA P; OLIVA S; RIZZON P;
Indirizzi:
UNIV CAGLIARI,IST CARDIOL,VIA SAN GIORGIO 12 CAGLIARI ITALY UNIV BARI,INST CARDIOL BARI ITALY
Titolo Testata:
European heart journal
fascicolo: 4, volume: 18, anno: 1997,
pagine: 618 - 624
SICI:
0195-668X(1997)18:4<618:FOMIIP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
TWO-DIMENSIONAL ECHOCARDIOGRAPHY; NO-REFLOW PHENOMENON; LOW-DOSE DOBUTAMINE; THROMBOLYTIC THERAPY; ELECTROCARDIOGRAPHIC EVIDENCE; PERFUSION; REPERFUSION; ABNORMALITIES; IMPROVEMENT; DYSFUNCTION;
Keywords:
MYOCARDIAL CONTRAST ECHOCARDIOGRAPHY; DOBUTAMINE ECHOCARDIOGRAPHY; MYOCARDIAL VIABILITY; MICROVASCULAR INTEGRITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
S. Iliceto et al., "FUNCTIONAL-ROLE OF MICROVASCULAR INTEGRITY IN PATIENTS WITH INFARCT-RELATED ARTERY PATENCY AFTER ACUTE MYOCARDIAL-INFARCTION", European heart journal, 18(4), 1997, pp. 618-624

Abstract

Aims The study was set up to evaluate the functional role of post-infarct preserved microvascular integrity. Low dose dobutamine echocardiography and myocardial contrast echocardiography were used to study patients before hospital discharge who had suffered a recent myocardial infarction and had a patent infarct-related artery (TIMI flow grade 3). Method In the dysfunctioning infarct area, the wall motion score index was calculated at baseline, during the dobutamine infusion and al the 3 month follow-up echocardiogram; contrast echocardiography was performed at the time of coronary angiography, before hospital discharge. Results In patients with more than 50% of the dysfunctioning infarct area opacified at contrast echocardiography (group A), regional wall motion score index decreased, compared to baseline, during the dobutamine infusion (1.97 +/- 0.78 vs 2.5 +/- 0.35 at baseline, P<0.001) and atfollow-up echocardiography (1.83 +/- 0.63 vs 2.5 +/- 0.35 at baseline; P<0.001). In patients with less extensive microvascular integrity asrevealed by contrast echocardiography (group B), regional wall motionscore index did not decrease from baseline during either the dobutamine infusion (2.73 +/- 0.21 vs 2.81 +/- 0.20 at baseline; P=ns) or at follow-up (2.81 +/- 0.20 vs 2 81 +/- 0.20 at baseline; P=ns). Conclusion In patients with post-infarct dysfunctioning myocardium but a patentinfarct-related artery, microvascular integrity, as assessed by myocardial contrast echocardiography, is an indicator of myocardial viability in terms of preserved contractile reserve, as demonstrated by dobutamine infusion and functional recovery at follow-up.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:28:10