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Titolo:
3-[I-123]IODO-ALPHA-METHYLTYROSINE AND [METHYL-C-11]-L-METHIONINE UPTAKE IN CEREBRAL GLIOMAS - A COMPARATIVE-STUDY USING SPECT AND PET
Autore:
LANGEN KJ; ZIEMONS K; KIWIT JCW; HERZOG H; KUWERT T; BOCK WJ; STOCKLIN G; FEINENDEGEN LE; MULLERGARTNER HW;
Indirizzi:
KFA JULICH GMBH,RES CTR,INST MED,POSTFACH 1913 D-52425 JULICH GERMANY KFA JULICH GMBH,RES CTR,INST NUCL CHEM D-52425 JULICH GERMANY UNIV DUSSELDORF,DEPT NUCL MED D-4000 DUSSELDORF GERMANY UNIV DUSSELDORF,DEPT NEUROSURG D-4000 DUSSELDORF GERMANY
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 4, volume: 38, anno: 1997,
pagine: 517 - 522
SICI:
0161-5505(1997)38:4<517:3A[U>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; AMINO-ACID-TRANSPORT; BRAIN-TUMORS; COMPUTED-TOMOGRAPHY; L-3-)I-123>IODO-ALPHA-METHYL TYROSINE; METHIONINE ACCUMULATION; PROTEIN-SYNTHESIS; GA-68 EDTA; COMPETITION; BIOPSIES;
Keywords:
AMINO ACIDS; 3-[I-123]IODO-ALPHA-METHYLTYROSINE; [METHYL-C-11]-L-METHIONINE; CEREBRAL GLIOMAS; SPECT; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
K.J. Langen et al., "3-[I-123]IODO-ALPHA-METHYLTYROSINE AND [METHYL-C-11]-L-METHIONINE UPTAKE IN CEREBRAL GLIOMAS - A COMPARATIVE-STUDY USING SPECT AND PET", The Journal of nuclear medicine, 38(4), 1997, pp. 517-522

Abstract

This study compares the uptake of the nonmetabolizable amino acid analog 3-[I-123]iodo-alpha-methyltyrosine (IMT) and of [methyl-C-11]-L-methionine (MET) in cerebral gliomas. Methods: In 14 patients with cerebral gliomas, IMT uptake was measured using SPECT (10 dynamic, 4 staticSPECT acquisitions) and, on the same day, MET uptake by dynamic PET. The IMT and MET data were compared with respect to tracer kinetics, tumor to brain ratios (T/B) and tumor size after converting the resolution of the PET scans to that of the SPECT scans (14 mm FWHM). Results: All gliomas showed increased uptake of both tracers in relation to normal brain tissue. Visual comparison of the scans yielded no differences in tumor size and shape with both methods. IMT showed a maximal tracer uptake in brain and in tumors at about 15 min postinjection which was followed by a washout of 45.0% +/- 13.5% in gliomas (mean +/- s.d.,p < 0.001, n = 10)and 35.3% +/- 5.4% in normal brain (p < 0.001, n = 10) at 60 min postinjection. MET concentration in tumor tissue or brain tissue between 15 and 60 min remained constant. T/B ratios of IMT SPECT and MET PET showed a significant correlation at 15 min postinjection (r = 0.69, n = 10, p = 0.03), a low correlation for the mean valuesof the scans from 15-60 min postinjection (r = 0.54, n = 14, p = 0.05) and no correlation at 60 min postinjection (r = 0.09, n = 10, n.s.). Conclusion: IMT and MET uptake in gliomas is similar in the early, transport dominated phase. There are some differences in tumor to brain ratios between both tracers within the first hour postinjection that are mainly caused by variable washout of IMT. Imaging of tumor extent with IMT SPECT is comparable to MET PET. Thus, amino acid SPECT using IMT is a promising tool to evaluate the biological activity and intracerebral infiltration of gliomas.

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Documento generato il 21/01/21 alle ore 06:59:13