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Titolo:
CORRECTION OF THE STEREOCHEMICAL ASSIGNMENT OF THE BENZILIC ACID CENTER IN (R)-(-)-3-QUINUCLIDINYL (S)-(-4-IODOBENZILATE [(R,S)-4-IQNB]())
Autore:
ZEEBERG BR; BOULAY SF; GITLER MS; SOOD VK; REBA RC;
Indirizzi:
GEORGE WASHINGTON UNIV,MED CTR,DEPT RADIOL,SECT RADIOPHARMACEUT CHEM,2300 EYE ST NW WASHINGTON DC 20037 UNIV CHICAGO HOSP,NUCL MED SECT,DEPT RADIOL CHICAGO IL 60637
Titolo Testata:
Applied radiation and isotopes
fascicolo: 4, volume: 48, anno: 1997,
pagine: 463 - 467
SICI:
0969-8043(1997)48:4<463:COTSAO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; POTENTIAL RADIOPHARMACEUTICALS; MUSCARINIC RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
B.R. Zeeberg et al., "CORRECTION OF THE STEREOCHEMICAL ASSIGNMENT OF THE BENZILIC ACID CENTER IN (R)-(-)-3-QUINUCLIDINYL (S)-(-4-IODOBENZILATE [(R,S)-4-IQNB]())", Applied radiation and isotopes, 48(4), 1997, pp. 463-467

Abstract

Radioiodinated (R)-quinuclidinyl-4-iodobenzilate (4IQNB) is a high affinity muscarinic antagonist which has been utilized for in vitro and in vivo assays, and for SPECT imaging in humans. 4IQNB exists in four different diastereomeric forms, since there are two asymmetric centersat the quinuclidinyl and benzilic acid centers. Based upon our in vivo studies, we have determined that the absolute stereochemistry previously assigned to the benzilic center was incorrect for the diastereomer that had been previously referred to as '(R)-quinuclidinyl-(R)-4-iodobenzilate' [(R,R)-4IQNB]. The correct designation for this diastereomer is '(R)-quinuclidinyl-(S)-4-iodobenzilate' [(R,S)-4IQNB]. (C) 1997 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 07:27:25