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Titolo:
THE ALVEOLAR TYPE-II CELL IS A PLURIPOTENTIAL STEM-CELL IN THE GENESIS OF HUMAN ADENOCARCINOMAS AND SQUAMOUS-CELL CARCINOMAS
Autore:
TENHAVEOPBROEK AAW; BENFIELD JR; VANKRIEKEN JHJH; DIJKMAN JH;
Indirizzi:
LEIDEN UNIV,DEPT ANAT & EMBRYOL,RESP BIOL GRP,POB 9602 NL-2300 RC LEIDEN NETHERLANDS LEIDEN UNIV,DEPT PNEUMOL LEIDEN NETHERLANDS UNIV CALIF DAVIS,DEPT CARDIOTHORAC SURG DAVIS CA 95616 LEIDEN UNIV,DEPT PATHOL LEIDEN NETHERLANDS
Titolo Testata:
Histology and histopathology
fascicolo: 2, volume: 12, anno: 1997,
pagine: 319 - 336
SICI:
0213-3911(1997)12:2<319:TATCIA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SURFACTANT-ASSOCIATED PROTEIN; EMBRYONIC MOUSE LUNG; ULTRASTRUCTURAL FEATURES; RESPIRATORY EPITHELIUM; EXPRESSION; DIFFERENTIATION; CYTOCHEMISTRY; MICROSCOPY; GESTATION; TISSUE;
Keywords:
ALVEOLAR TYPE II CELLS; HUMAN LUNG CARCINOGENESIS; LUNG ADENOCARCINOMAS; LUNG SQUAMOUS CELL CARCINOMAS; NONSMALL CELL LUNG CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
A.A.W. Tenhaveopbroek et al., "THE ALVEOLAR TYPE-II CELL IS A PLURIPOTENTIAL STEM-CELL IN THE GENESIS OF HUMAN ADENOCARCINOMAS AND SQUAMOUS-CELL CARCINOMAS", Histology and histopathology, 12(2), 1997, pp. 319-336

Abstract

Studies in a canine bronchogenic carcinoma model indicate that alveolar type II cells may differentiate from carcinogen-exposed epithelium of larger bronchi and generate adenocarcinomas with bronchioloalveolarand other growth patterns. In this study, we investigated whether type II cells are one of the major proliferating cells (=stem cells) in the genesis of two major subsets of bronchogenic carcinoma in humans. Adenocarcinomas (17 bronchioloalveolar; 3 papillary; and 10 other) and squamous cell carcinomas (n=27) as well as (pre)neoplastic lesions in adjacent bronchi and bronchioles were examined for the presence of type II cell markers and cellular proliferation markers (PCNA; Ki-67) using light and electron microscopy and immunohistochemistry. Distinctivefeatures of type II cells, which do not depend upon the degree of cell maturity, are the approximately cuboid shape, large and roundish nucleus, cytoplasmic staining for surfactant protein A (SP-A), and presence of multilamellar bodies or their precursory forms. Cells with this phenotype were found in early progressive (i.e., dysplastic, in situ, microinvasive) lesions in conducting airways and in all the carcinomasinvestigated, although with a much greater abundance among glandular lesions compared to squamous lesions. The most consistent sites of type II cells were the basal and adjacent epithelial layers. Nuclear PCNA(Ki-67) expression usually predominated in the same region. None of the lesions displayed specific Clara cell features. Our findings strongly suggest that the type LI cell is a pluripotential stem cell in human lung carcinogenesis. Based on our findings in humans and dogs, we postulate that type II tumor stem cells may originate from one of two sources: (1) normal bronchial epithelium (by an oncofetal mechanism of differentiation); and (2) normal alveolar type II cells.

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Documento generato il 04/12/20 alle ore 19:16:05