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Titolo:
CEREBROSPINAL-FLUID SOLUBLE INTERLEUKIN-2 RECEPTOR IN CEREBRAL LUPUS
Autore:
GILAD R; LAMPL Y; ESHEL Y; BARAK V; SAROVAPINHAS I;
Indirizzi:
EDITH WOLFSON MED CTR,DEPT NEUROL IL-58100 HOLON ISRAEL HADASSAH UNIV HOSP,ONCOL LAB EIN KEREM ISRAEL TEL AVIV UNIV IL-69978 TEL AVIV ISRAEL
Titolo Testata:
British journal of rheumatology
fascicolo: 2, volume: 36, anno: 1997,
pagine: 190 - 193
SICI:
0263-7103(1997)36:2<190:CSIRIC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVOUS-SYSTEM INVOLVEMENT; NEUROLOGICAL DISORDERS; DISEASE-ACTIVITY; IGG ANALYSES; SERUM LEVELS; ERYTHEMATOSUS; ANTIBODIES; VASCULITIS; PRINCIPLES; ALBUMIN;
Keywords:
INTERLEUKIN; SYSTEMIC LUPUS; STROKE; CEREBRAL LUPUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
R. Gilad et al., "CEREBROSPINAL-FLUID SOLUBLE INTERLEUKIN-2 RECEPTOR IN CEREBRAL LUPUS", British journal of rheumatology, 36(2), 1997, pp. 190-193

Abstract

Cerebrospinal fluid (CSF) and serum samples of 20 young adults (mean age 41 +/- 3.4 yr) with a first episode of stroke were tested for interleukin-2 (IL-2), soluble interleukin-2 receptor (SIL-2R), tumour necrosis factor-alpha (TNF-alpha) and interleukin-l-beta (IL-1 beta) levels. The results were compared to 20 patients who had neurological symptoms without evidence of a neurological disease. Three subgroups were formed according to the aetiological source of the stroke, determined by the neurological examination and evaluation. In 13 patients, the presence of atheromatous carotid plaque or cardiac disease was found. In five of the patients, stroke was the presenting symptom of systemic lupus erythematosus (SLE), which developed during the follow-up period. In two patients, no obvious aetiology could be demonstrated. The SIL-2R level was significantly higher in the CSF of patients who later developed definite SLE (P = 0.001). Other CSF interleukins and all serum interleukin levels were not significantly different in any of the groups. No correlation between albumin quotient and CSF SIL-2R was found. The SIL-2R level in the CSF may be used as a diagnostic tool to differentiate immunologically mediated vascular processes in the CNS from stroke of other origin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:44:35