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Titolo:
BLADDER-CARCINOMA AND OTHER 2ND MALIGNANCIES AFTER RADIOTHERAPY FOR PROSTATE CARCINOMA
Autore:
NEUGUT AI; AHSAN H; ROBINSON E; ENNIS RD;
Indirizzi:
COLUMBIA PRESBYTERIAN MED CTR,DIV ONCOL,630 W 168TH ST NEW YORK NY 10032 COLUMBIA UNIV COLL PHYS & SURG,DEPT MED NEW YORK NY 10032 COLUMBIA UNIV COLL PHYS & SURG,SCH PUBL HLTH NEW YORK NY 10032 RAMBAM MED CTR,NO ISRAEL ONCOL CTR HAIFA ISRAEL COLUMBIA UNIV COLL PHYS & SURG,DEPT RADIAT ONCOL NEW YORK NY 10032
Titolo Testata:
Cancer
fascicolo: 8, volume: 79, anno: 1997,
pagine: 1600 - 1604
SICI:
0008-543X(1997)79:8<1600:BAO2MA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER REGISTRIES; CERVICAL-CANCER;
Keywords:
PROSTATE CARCINOMA; BLADDER CARCINOMA; 2ND MALIGNANT NEOPLASMS; RADIATION; RADIATION THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
A.I. Neugut et al., "BLADDER-CARCINOMA AND OTHER 2ND MALIGNANCIES AFTER RADIOTHERAPY FOR PROSTATE CARCINOMA", Cancer, 79(8), 1997, pp. 1600-1604

Abstract

BACKGROUND. Radiation therapy (RT) to the pelvis has been associated with an increased risk of bladder carcinoma, as well as other malignancies. However, no controlled studies have previously explored the riskof second malignancies after RT for prostate carcinoma. METHODS. A retrospective cohort study was conducted utilizing data from the Surveillance, Epidemiology, and End Results Program (SEER) of the U.S. National Cancer Institute from 1973-1990. The standardized incidence ratio (SIR), adjusted for age, was calculated as an estimate of the relative risk (RR) of developing a second malignancy after prostate carcinoma for radiated and nonradiated prostate carcinoma patients separately. RESULTS. The cohort was comprised of 34,889 prostate carcinoma patients who had undergone RT, and 106,872 who had not. After 8 years, the riskof bladder carcinoma was elevated for the RT group (RR 1.5; 95% confidence interval [CI], 1.1-2.0) but not for the non-RT group (RR 1.0; 95% CI, 0.7-1.2). There was an elevated risk of bladder carcinoma for the RT group at 5-8 years as well (RR 1.3; 95% CI, 1.0-1.7). No elevations in risk were observed for rectal carcinoma, acute nonlymphocytic leukemia, or chronic lymphocytic leukemia for either RT patients or non-RT patients. CONCLUSIONS. The risk of bladder carcinoma is elevated several years after RT for prostate carcinoma, but this elevation is notdramatic, There is no increased risk of rectal carcinoma or leukemia after this type of radiation exposure. (C) 1997 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 01:49:33