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Titolo:
RISK-FACTORS FOR INTRAHEPATIC RECURRENCE OF HEPATOCELLULAR-CARCINOMA IN CIRRHOTIC-PATIENTS TREATED BY PERCUTANEOUS ETHANOL INJECTION
Autore:
POMPILI M; RAPACCINI GL; DELUCA F; CATURELLI E; ASTONE A; SIENA DA; VILLANI MR; GRATTAGLIANO A; CEDRONE A; GASBARRINI G;
Indirizzi:
UNIV CATTOLICA SACRO CUORE,CATTEDRA MED INTERNA 2,LARGO A GEMELLI 8 I-00168 ROME ITALY UNIV CATTOLICA SACRO CUORE,CATTEDRA MED INTERNA 2 I-00168 ROME ITALY IRCCS,CASA SOLLIEVO SOFFERENZA,DIV GASTROENTEROL SAN GIOVANNI ROTO FGITALY
Titolo Testata:
Cancer
fascicolo: 8, volume: 79, anno: 1997,
pagine: 1501 - 1508
SICI:
0008-543X(1997)79:8<1501:RFIROH>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM ALPHA-FETOPROTEIN; COMPLICATING CIRRHOSIS; TUMOR RECURRENCE; LIVER-CIRRHOSIS; RESECTION;
Keywords:
HEPATOCELLULAR CARCINOMA; CIRRHOSIS; PERCUTANEOUS ETHANOL INJECTION; LONG TERM SURVIVAL; RECURRENCE RATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
M. Pompili et al., "RISK-FACTORS FOR INTRAHEPATIC RECURRENCE OF HEPATOCELLULAR-CARCINOMA IN CIRRHOTIC-PATIENTS TREATED BY PERCUTANEOUS ETHANOL INJECTION", Cancer, 79(8), 1997, pp. 1501-1508

Abstract

BACKGROUND. Hepatocellular carcinoma (HCC) complicating cirrhosis hasa high intrahepatic recurrence rate after treatment by surgical resection or percutaneous ethanol injection (PEI). In this study, certain clinical, biochemical, and pathologic parameters were evaluated as riskfactors for intrahepatic tumor recurrence in liver segments differentfrom that of the first neoplasm in a group of 57 cirrhotic patients with single HCC < 5 cm treated by PEI. METHODS. After PEI treatment of HCC, the patients were followed for a mean period of 33 +/- 16 months. The following pretreatment parameters were evaluated as predictors oftumor recurrence: age, gender, Child-Pugh score, hepatitis B virus surface antigen, hepatitis C virus antibodies, alanine aminotransferase,aspartate aminotransferase, alpha-fetoprotein (AFP) level before PEI,alcohol abuse, HCC size, HCC ultrasound pattern, HCC histologic grade, HCC capsule, and time from cirrhosis diagnosis. Furthermore, the posttreatment parameters of the AFP level 1 month after PEI and recurrence of HCC in the same liver segment were also evaluated. RESULTS. The cumulative 4-year intrahepatic recurrence rate of HCC was 62%. The log rank test indicated that, among pretreatment parameters, time from cirrhosis diagnosis >6 years (P = 0.05) and AFP level before PEI of >25 ng/mL (P = 0.00005) were significantly linked to tumor recurrence. Cox's proportional hazards model showed that only AFP level before PEI wasindependently associated with recurrence (P < 0.002). With regard to posttreatment parameters, an AFP level 1 month after PEI of >13 ng/mL was shown to be significantly related to tumor recurrence by the log rank test (P < 0.0001). CONCLUSIONS. Cirrhotic patients with single HCCtreated by PEI who have slightly increased serum levels of AFP beforeand/or after PEI treatment are at increased risk of intrahepatic tumor recurrence and should undergo a close follow-up program. (C) 1997 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 04:25:22