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Titolo:
POTENT INHIBITION OF RESPIRATORY SYNCYTIAL VIRUS BY POLYOXOMETALATES OF SEVERAL STRUCTURAL CLASSES
Autore:
BARNARD DL; HILL CL; GAGE T; MATHESON JE; HUFFMAN JH; SIDWELL RW; OTTO MI; SCHINAZI RF;
Indirizzi:
UTAH STATE UNIV,DEPT ANIM DAIRY & VET SCI,INST ANTIVIRAL RES LOGAN UT84322 EMORY UNIV,DEPT CHEM ATLANTA GA 30033 AVID THERAPEUT INC PHILADELPHIA PA 19104 EMORY UNIV,VA MED CTR DECATUR GA 30033
Titolo Testata:
Antiviral research
fascicolo: 1, volume: 34, anno: 1997,
pagine: 27 - 37
SICI:
0166-3542(1997)34:1<27:PIORSV>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-PROPERTIES; ATTACHMENT PROTEIN; ANTIVIRAL ACTIVITY; HETEROPOLYANION; RETROVIRUSES; GLYCOPROTEIN; MYXOVIRUSES; INVITRO; TYPE-1;
Keywords:
RESPIRATORY SYNCYTIAL VIRUS; POLYOXOMETALATE; ANTIVIRAL; CYTOPATHIC INHIBITION ASSAY; NEUTRAL RED UPTAKE ASSAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
D.L. Barnard et al., "POTENT INHIBITION OF RESPIRATORY SYNCYTIAL VIRUS BY POLYOXOMETALATES OF SEVERAL STRUCTURAL CLASSES", Antiviral research, 34(1), 1997, pp. 27-37

Abstract

A series of polyoxometalates (POM) were synthesized and evaluated foranti-respiratory syncytial virus (RSV) activity. POM containing zirconium, tungsten, silicon, platinum, niobium or germanium of a variety of structural types have been evaluated. Sixteen of the compounds had very striking anti-RSV activity against a clinical isolate, Utah 89, with median effective concentration (EC(50)) values less than or equal to 3 mu M and selective indices > 80 as determined by viral cytopathic inhibition effect, neutral red uptake and virus yield reduction assays. The EC(50) values for all three assays correlated very well (Pearsoncorrelation coefficients > 0.90>. POM containing sodium cations were totally inactive. Germanium-, niobium-, tin: and zirconium-containing compounds were found to be highly potent and selective. The antiviral activity was not cell line-dependent. The median cytotoxic concentration (IC50) values were generally greater than 100 mu M. The compounds were also comparably active against a known laboratory RSV strain, A2, as well as other RSV strains. To detect any virus strain-specific inhibitory activity, seven POM were tested against other RSV strains; all were nearly equally inhibitory to the human virus strains, suggesting no strain specificity. Timing studies suggested that these compounds were most inhibitory during virus adsorption and penetration, although RSV. was still Significantly inhibited when the compound was added 3 hpost-infection; which is considered well into the eclipse period. These data suggest that these potent, non-toxic compounds should be further studied as potential chemotherapeutic agents for treating RSV infections. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 03:53:19