Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MONITORING OF FUNCTIONAL-CHANGES AFTER TRANSIENT ISCHEMIA IN GERBIL COCHLEA
Autore:
MOM T; AVAN P; ROMAND R; GILAIN L;
Indirizzi:
FAC MED,DEPT BIOPHYS,POB 38 F-63001 CLERMONT FERRAN FRANCE UNIV AUVERGNE,SCH MED,LAB AUTIT F-63001 CLERMONT FERRAN FRANCE UNIV AUVERGNE,SCH MED,ENT DEPT F-63001 CLERMONT FERRAN FRANCE UNIV CLERMONT FERRAND,NEUROBIOL LAB,ENSEMBLE SCI CEZEAUX F-63177 CLERMONT FERRAN FRANCE
Titolo Testata:
Brain research
fascicolo: 1, volume: 751, anno: 1997,
pagine: 20 - 30
SICI:
0006-8993(1997)751:1<20:MOFATI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRODUCT OTOACOUSTIC EMISSIONS; ACOUSTIC DISTORTION PRODUCTS; OUTER HAIR-CELLS; FOREBRAIN ISCHEMIA; CEREBRAL-ISCHEMIA; BASILAR-MEMBRANE; REPERFUSION; DAMAGE; RAT; AMPLIFIER;
Keywords:
REVERSIBLE ISCHEMIA; REPERFUSION; BLOOD FLOW; COCHLEA; OTOACOUSTIC EMISSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
T. Mom et al., "MONITORING OF FUNCTIONAL-CHANGES AFTER TRANSIENT ISCHEMIA IN GERBIL COCHLEA", Brain research, 751(1), 1997, pp. 20-30

Abstract

Ischemia and reperfusion are involved in numerous sensorineural pathologies. A model of reversible cochlear ischemia has been designed in Mongolian gerbil. Selective labyrinthine ischemia of variable duration (4-10 min) was achieved through a posterior transcranial approach. Ischemia and reperfusion were controlled with the help of laser Doppler velocimetry. Functional changes were monitored every 1-10 s throughout experiments, using cochlear potentials and otoacoustic emissions. After interruption of blood flow, all signals rapidly began to decay. In contrast to cochlear potentials, otoacoustic emissions always exhibiteda plateau before reaching noise floor only after approximate to 4-5 min. Upon ischemia release, cochlear blood flow recovered instantly andcompletely and cochlear potentials rapidly improved in most cases, incontrast to otoacoustic emissions that underwent a delayed decay after immediate partial recovery. The phase and group latency of otoacoustic emissions exhibited only small changes throughout ischemia and reperfusion, suggesting adaptive rather than damaging mechanisms. Cochlearfunction returned to normal after 5 min 30 s ischemia but longer complete ischemia sometimes led to irreversible damage despite the systematic presence of some recovery just after ischemia release. This behavior suggests that reperfusion in itself can be deleterious to a sensorineural organ and this model can be useful for identifying the noxious mechanisms of ischemia and reperfusion. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 08:28:10