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Titolo:
CELL-DEATH CAUSED BY THE ACUTE EFFECTS OF AMINOGLYCOSIDE AND ZINC IN THE AMPULLARY CRISTAE OF GUINEA-PIGS
Autore:
NAKAGAWA T; YAMANE H; SHIBATA S; SUNAMI K; NAKAI Y;
Indirizzi:
YODOGAWA CHRISTIANS HOSP,DEPT OTORHINOLARYNGOL,HIGASHIYODOGAWA KU,2-9-26 AWAJI OSAKA 533 JAPAN OSAKA CITY UNIV,SCH MED,DEPT OTORHINOLARYNGOL OSAKA 545 JAPAN
Titolo Testata:
European archives of oto-rhino-laryngology
fascicolo: 3, volume: 254, anno: 1997,
pagine: 153 - 157
SICI:
0937-4477(1997)254:3<153:CCBTAE>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
OUTER HAIR-CELLS; GENTAMICIN OTOTOXICITY; HEARING-LOSS; APOPTOSIS; DNA;
Keywords:
APOPTOSIS; LABYRINTHINE VESTIBULE; AMINOGLYCOSIDE TOXICITY; ZINC TOXICITY; NICK-END LABELING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
T. Nakagawa et al., "CELL-DEATH CAUSED BY THE ACUTE EFFECTS OF AMINOGLYCOSIDE AND ZINC IN THE AMPULLARY CRISTAE OF GUINEA-PIGS", European archives of oto-rhino-laryngology, 254(3), 1997, pp. 153-157

Abstract

We reported that apoptosis occurred in the guinea pig vestibular haircells after chronic aminoglycoside treatments. In the present study, we used in situ nick-end labeling to determine whether apoptosis was also induced by the acute effects of aminoglycosides in guinea pig ampullar cristae. In addition, we evaluated the effect of zinc supplementsupon these ototoxic treatments. After a local application of streptomycin directly to the round window, we found labeled bodies in the vestibular hair cells. The zinc supplement increased the number of labeledbodies resulting in severe hair cell loss. These findings indicate that the acute effects of aminoglycosides also induce apoptosis of the vestibular hair cells, and that zinc enhances aminoglycoside ototoxicity. Consequently, we propose that an interaction with ion channels may play a key mechanism in the processes of apoptosis affecting the vestibular hair cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 14:08:38