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Titolo:
Z-DNA CRYSTALLOGRAPHY
Autore:
HO PS; MOOERS BHM;
Indirizzi:
OREGON STATE UNIV,DEPT BIOCHEM & BIOPHYS,ALSB 2011 CORVALLIS OR 97331
Titolo Testata:
Biopolymers
fascicolo: 1, volume: 44, anno: 1997,
pagine: 65 - 90
SICI:
0006-3525(1997)44:1<65:ZC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HANDED Z-DNA; TO-Z TRANSITION; B-Z TRANSITION; SOLVENT-ACCESSIBLE SURFACES; PURINE-PYRIMIDINE SEQUENCES; SINGLE-CRYSTAL STRUCTURE; 1.0-A ATOMIC RESOLUTION; PURE-SPERMINE FORM; BASE-PAIRS; MOLECULAR-STRUCTURE;
Keywords:
Z-DNA; SINGLE CRYSTALS; NUCLEOTIDE; HYDRATION; CONFORMATION; POLYMERS; GENOMIC SEQUENCES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
121
Recensione:
Indirizzi per estratti:
Citazione:
P.S. Ho e B.H.M. Mooers, "Z-DNA CRYSTALLOGRAPHY", Biopolymers, 44(1), 1997, pp. 65-90

Abstract

We review the effect of sequence on the structure of left-handed Z-DNA in single crystals. The various substituent groups that define a nucleotide base as guanine, cytosine, thymine, or adenine affect both theDNA conformation ann the organization of solvent around the duplex. These are discussed in terms of their effect on the ability of sequences to adopt the unusual Z-DNA structure. In addition, the experimental and theoretical methods used to treat DNA hydration are discussed as they relate to the stability of Z-DNA. Finally, we argue that Z-DNA, asdefined by the crystal conformation, is sufficient in itself to account for the physical properties of left-handed conformations observed in polymers and in genomic sequences. (C) 1997 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:00:34