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Titolo:
AMINO-ACID-CONCENTRATIONS IN HYPOTHALAMIC AND CAUDATE NUCLEI DURING MICROWAVE-INDUCED THERMAL-STRESS - ANALYSIS BY MICRODIALYSIS
Autore:
MASON PA; ESCARCIGA R; DOYLE JM; ROMANO WF; BERGER RE; DONNELLAN JP;
Indirizzi:
USAF,ARMSTRONG LAB,OERB,BLDG 1182,8308 HAWKS RD BROOKS AFB TX 78235 SYST RES LABS INC SAN ANTONIO TX 00000 OPERAT TECHNOL CORP SAN ANTONIO TX 00000 USAF,ARMSTRONG LAB,RADIOFREQUENCY RADIAT DIV BROOKS AFB TX 78235
Titolo Testata:
Bioelectromagnetics
fascicolo: 3, volume: 18, anno: 1997,
pagine: 277 - 283
SICI:
0197-8462(1997)18:3<277:AIHACN>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCALIZED HYPERTHERMIA; BRAIN; GLUTAMATE; RECEPTORS; NEUROTRANSMITTERS; THERMOREGULATION; DECEREBRATE; INVOLVEMENT; ELEVATION; ASPARTATE;
Keywords:
AMINO ACIDS; ELECTROMAGNETIC FIELDS; HIGH-PRESSURE LIQUID CHROMATOGRAPHY; NEUROCHEMISTRY; RADIOFREQUENCY RADIATION; THERMOREGULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
P.A. Mason et al., "AMINO-ACID-CONCENTRATIONS IN HYPOTHALAMIC AND CAUDATE NUCLEI DURING MICROWAVE-INDUCED THERMAL-STRESS - ANALYSIS BY MICRODIALYSIS", Bioelectromagnetics, 18(3), 1997, pp. 277-283

Abstract

Exposure to radiofrequency radiation (RFR) may produce thermal responses. Extracellular amino acid concentrations in the hypothalamus (Hyp)and caudate nucleus (CN) were measured by using in vivo microdialysisbefore and during exposure to RFR. Under urethane anesthetic, each rat was implanted stereotaxically with a nonmetallic microdialysis probeand temperature probe guides and then placed in the exposure chamber. The rat laid on its right side with its head and neck placed directlyunder the wave guide. Temperature probes were placed in the left brain, right brain, face (subcutaneously), left tympanum, and rectum. Eachmicrodialysis sample was collected over a 20 min period. The microdialysis probe was perfused for 2 h before the rat was exposed to 5.02 GHz radiation (10 mu s pulse width, 1000 pulses/s). The right and left sides of the brain were maintained at approximately 41.2 and 41.7 degrees C, respectively, throughout a 40 min exposure period. Initially when the brain was being heated to these temperatures, the time-averaged specific absorption rates (SARs) for the right and left sides of the brain were 29 and 40 W/kg, respectively. Concentrations of aspartic acid, glutamic acid, serine, glutamine, and glycine in dialysate were determined by using high-pressure Liquid chromatography with electrochemical detection. In the Hyp and CN, the concentrations of aspartic acid,serine, and glycine increased significantly during RFR exposure (P <.05). These results indicate that RFR-induced thermal stress produces ageneral change in the amino acid concentrations that is not restricted to thermoregulatory centers. Changes in the concentrations of glutamic acid (Hyp, P = .16; CN, P = .34) and glutamine (Hyp, P = .13; CN, P= .10) were not statistically significant Altered amino acid concentrations may reveal which brain regions are susceptible to damage in response to RFR-induced thermal stress. (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:32:11