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Titolo:
PRETREATMENT WITH QUINPIROLE INHIBITS THE CENTRAL ANTIHYPERTENSIVE EFFECTS OF RILMENIDINE AND ALPHA-METHYLDOPA IN CONSCIOUS RATS
Autore:
VANDENBUUSE M;
Indirizzi:
BAKER MED RES INST,COMMERCIAL RD,POB 348 PRAHRAN VIC 3181 AUSTRALIA
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 322, anno: 1997,
pagine: 191 - 199
SICI:
0014-2999(1997)322:2-3<191:PWQITC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; DOPAMINE-D2 RECEPTOR AGONIST; BLOOD-PRESSURE; PARKINSONS-DISEASE; VASOPRESSIN; LY171555; NUCLEUS; QUINELORANE; WITHDRAWAL; PERGOLIDE;
Keywords:
QUINPIROLE; DOPAMINE; DOPAMINE D-2 RECEPTOR; RILMENIDINE; ALPHA-METHYLDOPA; HYDRALAZINE; SYMPATHETIC NERVOUS SYSTEM; VASOPRESSIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
M. Vandenbuuse, "PRETREATMENT WITH QUINPIROLE INHIBITS THE CENTRAL ANTIHYPERTENSIVE EFFECTS OF RILMENIDINE AND ALPHA-METHYLDOPA IN CONSCIOUS RATS", European journal of pharmacology, 322(2-3), 1997, pp. 191-199

Abstract

Treatment of conscious spontaneously hypertensive rats (SHR) with thedopamine D-2 receptor agonist quinpirole causes a short-lasting pressor response and apparent desensitisation to the effects of subsequent injections of quinpirole or central antihypertensives such as clonidine. In the present study, a number of aspects of this apparent desensitisation were investigated. Thirty minutes after intravenous injection of quinpirole into spontaneously hypertensive rats, treatment with thedopamine D-2 receptors antagonist raclopride caused a significant fall in blood pressure. At this time point, circulating levels of vasopressin were not significantly different compared to controls. In Brattleboro rats, the presser response to quinpirole was reduced in the first15 min after injection, but no difference in blood pressure was observed at later time points. In SHR which had been treated with quinpirole, the central antihypertensive effects of rilmenidine or alpha-methyldopa were significantly inhibited. By contrast, the bradycardia induced by these drugs was similar in quinpirole-treated rats and controls. Quinpirole pretreatment caused an enhancement of the hypotension but areduction of the reflex tachycardia after intravenous treatment with hydralazine. In SHR treated with methylatropine and quinpirole, the upper plateau of the sympathetic baroreceptor-heart rate reflex curve was reduced. These results show that treatment with quinpirole has marked effects on central sympathetic vasomotor mechanisms which are the target of antihypertensive drugs such as rilmenidine and alpha-methyldopa. At least some of these effects may occur at the level of the sympathetic baroreflex. Moreover, while the effects of quinpirole on sympathetic regulation are prolonged, the initial presser response is counteracted by an as yet unidentified compensatory mechanism which can be unmasked when quinpirole is displaced from its receptor by dopamine D-2,receptor antagonist treatment. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 12:10:15