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Titolo:
ALTERED BEHAVIORAL SENSITIVITY OF CA2-MODULATING DRUGS AFTER CHRONIC NICOTINE ADMINISTRATION IN MICE()
Autore:
DAMAJ MI;
Indirizzi:
VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOLRICHMOND VA 23298
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 322, anno: 1997,
pagine: 129 - 135
SICI:
0014-2999(1997)322:2-3<129:ABSOCD>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CULTURED CORTICAL-NEURONS; HIGH-CALCIUM PERMEABILITY; ACETYLCHOLINE-RECEPTORS; PROTEIN-PHOSPHORYLATION; INDUCED ANTINOCICEPTION; CONDITIONED TOLERANCE; PC12 CELLS; RELEASE; CORTICOSTERONE; ANTAGONISTS;
Keywords:
NICOTINE; ANTINOCICEPTION; CA2+; CA2+ CHANNEL; TOLERANCE; THAPSIGARGIN; (INTHRATHECAL);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
M.I. Damaj, "ALTERED BEHAVIORAL SENSITIVITY OF CA2-MODULATING DRUGS AFTER CHRONIC NICOTINE ADMINISTRATION IN MICE()", European journal of pharmacology, 322(2-3), 1997, pp. 129-135

Abstract

Numerous studies have demonstrated that tolerance develops to the physiological and behavioral effects of nicotine in animals after chronicadministration of the drug. However, the mechanisms underlying tolerance to nicotine are not well known. There are several lines of evidence which support a role for Ca2+ in nicotine's acute pharmacological effects. The objective of the study was to determine whether Ca2+ plays a role in the development of tolerance to nicotine by investigating the behavioral activity of several Ca2+ modulating drugs after systemic (BAY K 8644: l-5-nitro-4-[2-(trifluromethyl)-phenyl]-3-pyridine carboxylic acid methyl ester) and intrathecal administration (BAY K 8644, Ca2+ and thapsigargin) in nicotine-tolerant mice. The ability of BAY K 8644 to induce motor impairment and hypomotility after i.p. injection was decreased in nicotine-tolerant mice. Ln addition, tolerance to Ca2thapsigargin, and BAY K 8644-induced antinociception after i.t. injection also developed in nicotine-tolerant mice. ED(50) values for BAY K8644 and thapsigargin increased from 3.7 to 12 mu g/mouse and 0.83 to19.7 mu g/mouse, respectively. The greatest tolerance developed to the effects of thapsigargin with an ED(50) value that increased from 0.83 to 20 mu g Furthermore, chronic nicotine injections did not alter [H-3]nitrendipine binding in the brain. These results suggest the involvement of Ca2+-dependent mechanisms in nicotine tolerance in mice. (C) 1997 Elsevier Science B.V.

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Documento generato il 22/09/20 alle ore 17:24:28