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Titolo:
INVERSION OF MORAXELLA-LACUNATA TYPE-4 PILIN GENE-SEQUENCES BY A NEISSERIA-GONORRHOEAE SITE-SPECIFIC RECOMBINASE
Autore:
ROZSA FW; MEYER TF; FUSSENEGGER M;
Indirizzi:
UNIV MICHIGAN,WK KELLOGG EYE CTR,1000 WALL ST ANN ARBOR MI 48105 UNIV BASEL,BIOCTR,DEPT MICROBIOL CH-4056 BASEL SWITZERLAND ETH HONGGERBERG,SWISS FED INST TECHNOL,INST BIOTECHNOL CH-8093 ZURICHSWITZERLAND MAX PLANCK INST BIOL,INFEKT BIOL ABT D-72076 TUBINGEN GERMANY MAX PLANCK INST INFEKT BIOL,MOL BIOL ABT D-10117 BERLIN GERMANY
Titolo Testata:
Journal of bacteriology
fascicolo: 7, volume: 179, anno: 1997,
pagine: 2382 - 2388
SICI:
0021-9193(1997)179:7<2382:IOMTPG>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PILUS ANTIGENIC VARIATION; CLONING VECTORS; PHASE VARIATION; RNA-POLYMERASE; DNA INVERSION; PROTEIN; TRANSFORMATION; EXPRESSION; ELEMENTS; SURFACE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
F.W. Rozsa et al., "INVERSION OF MORAXELLA-LACUNATA TYPE-4 PILIN GENE-SEQUENCES BY A NEISSERIA-GONORRHOEAE SITE-SPECIFIC RECOMBINASE", Journal of bacteriology, 179(7), 1997, pp. 2382-2388

Abstract

A plasmid library of Neisseria gonorrhoeae sequences was screened forthe ability to mediate recombinations on a sequence containing the Moraxella lacunata type 4 pilin gene invertible region in Escherichia coli. A plasmid containing the N. gonorrhoeae sequence encoding the putative recombinase (gcr) was identified and sequenced. Plasmids containing gcr were able to mediate site-specific recombinations despite a weak amino acid homology to Piv, the native M. lacunata pilin gene invertase. The gcr gene is present only in pathogenic strains of Neisseria tested; however, in our assays gene knockouts of gcr did not alter the variation of surface features that play a role in the pathogenesis of N. gonorrhoeae.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 16:05:38