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Titolo:
STREPTOZOTOCIN-INDUCED DIABETES PROVOKES CHANGES IN SEROTONIN CONCENTRATION AND ON 5-HT1A AND 5-HT2 RECEPTORS IN THE RAT-BRAIN
Autore:
SANDRINI M; VITALE G; VERGONI AV; OTTANI A; BERTOLINI A;
Indirizzi:
UNIV MODENA,DEPT BIOMED SCI,PHARMACOL SECT,VIA G CAMPI 287 I-41100 MODENA MO ITALY
Titolo Testata:
Life sciences
fascicolo: 16, volume: 60, anno: 1997,
pagine: 1393 - 1397
SICI:
0024-3205(1997)60:16<1393:SDPCIS>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELLITUS; STRESS;
Keywords:
STREPTOZOTOCIN; DIABETES; SEROTONIN; 5-HT1A RECEPTOR; 5-HT2 RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M. Sandrini et al., "STREPTOZOTOCIN-INDUCED DIABETES PROVOKES CHANGES IN SEROTONIN CONCENTRATION AND ON 5-HT1A AND 5-HT2 RECEPTORS IN THE RAT-BRAIN", Life sciences, 60(16), 1997, pp. 1393-1397

Abstract

Since reduced levels of brain serotonin are known to cause behavioural abnormalities, to which diabetics are also prone, we investigated the effect, in rats, of chronic diabetes on brain serotonin concentration and on the numbers of 5-HT1A and 5-HT2 receptors in cerebral cortex and brainstem. Our data show that streptozotocin induces a longlastinghyperglicemia that is associated with a decrease in cerebral concentration of serotonin and with an accompanying increase in the maximum number of 5-HT1A and 5-HT2 receptors in the brain areas studied. Our results may suggest that changes in serotonergic transmission in the CNS play a role in diabetes-related behavioural abnormalities.

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Documento generato il 01/10/20 alle ore 07:25:27