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Titolo:
LIPID-BASED VEHICLES FOR THE ORAL DELIVERY OF POORLY WATER-SOLUBLE DRUGS
Autore:
HUMBERSTONE AJ; CHARMAN WN;
Indirizzi:
MONASH UNIV,VICTORIAN COLL PHARM,DEPT PHARMACEUT,PARKVILLE CAMPUS,381ROYAL PARADE PARKVILLE VIC 3052 AUSTRALIA MONASH UNIV,VICTORIAN COLL PHARM,DEPT PHARMACEUT PARKVILLE VIC 3052 AUSTRALIA
Titolo Testata:
Advanced drug delivery reviews
fascicolo: 1, volume: 25, anno: 1997,
pagine: 103 - 128
SICI:
0169-409X(1997)25:1<103:LVFTOD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIUM-CHAIN TRIGLYCERIDES; PHYSICAL-CHEMICAL BEHAVIOR; NON-DISINTEGRATING TABLETS; ALPHA-TOCOPHEROL ACETATE; ADULT HUMAN-BEINGS; INTESTINAL-ABSORPTION; MICROEMULSION FORMULATION; FAT DIGESTION; DOSAGE FORMS; BILE-SALTS;
Keywords:
LIPIDS; LIPID DIGESTION; POORLY WATER SOLUBLE DRUGS; BIOAVAILABILITY; DOSE FORM PERFORMANCE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
105
Recensione:
Indirizzi per estratti:
Citazione:
A.J. Humberstone e W.N. Charman, "LIPID-BASED VEHICLES FOR THE ORAL DELIVERY OF POORLY WATER-SOLUBLE DRUGS", Advanced drug delivery reviews, 25(1), 1997, pp. 103-128

Abstract

The use of natural and synthetic lipids has generated much academic and commercial interest as a potential formulation strategy for improving the oral bioavailability of poorly water soluble drugs. Lipid-basedformulations can reduce the inherent limitations of slow and incomplete dissolution of poorly water soluble drugs, and facilitate the formation of solubilised phases from which absorption may occur. The attainment of an appropriate pre-absorptive solubilised phase will not necessarily arise directly from the administered lipid, but most likely from the intraluminal processing to which lipids-are subjected. This review attempts to provide a framework for the assessment of lipid based formulations by describing how aspects of GI physiology, and the choiceof lipids and their formulation attributes, impact on dose form performance. Lipid digestion is briefly described and the various colloidalphases present within the GI tract during lipid digestion:are highlighted. This is followed by selected examples where lipids have been investigated for improving the absorption of poorly water soluble drugs. Finally, some perspectives are offered such that the design of lipid-based dose forms may become less phenomenological than has been the traditional practice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:31:25