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Titolo:
ACTIVATION OF HER4 BY HEPARIN-BINDING EGF-LIKE GROWTH-FACTOR STIMULATES CHEMOTAXIS BUT NOT PROLIFERATION
Autore:
ELENIUS K; PAUL S; ALLISON G; SUN J; KLAGSBRUN M;
Indirizzi:
CHILDRENS HOSP,DEPT SURG BOSTON MA 02115 CHILDRENS HOSP,DEPT SURG BOSTON MA 02115 CHILDRENS HOSP,DEPT PATHOL BOSTON MA 02115 HARVARD UNIV,SCH MED BOSTON MA 02115 AMGEN INC,DEPT MOL BIOL THOUSAND OAKS CA 91320
Titolo Testata:
EMBO journal
fascicolo: 6, volume: 16, anno: 1997,
pagine: 1268 - 1278
SICI:
0261-4189(1997)16:6<1268:AOHBHE>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; PHOSPHATIDYLINOSITOL 3-KINASE; RECEPTOR FAMILY; TYROSINE PHOSPHORYLATION; SIGNAL TRANSDUCTION; KINASE-ACTIVITY; PROTEIN; HEREGULIN; LIGAND; ERBB3;
Keywords:
EGF; EGF RECEPTORS; HEREGULIN; PHOSPHATIDYLINOSITOL 3-KINASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
K. Elenius et al., "ACTIVATION OF HER4 BY HEPARIN-BINDING EGF-LIKE GROWTH-FACTOR STIMULATES CHEMOTAXIS BUT NOT PROLIFERATION", EMBO journal, 16(6), 1997, pp. 1268-1278

Abstract

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a potent mitogen and chemotactic factor for fibroblasts, smooth muscle cells and keratinocytes. It is demonstrated that HB-EGF is not onlya ligand for HER1, as previously reported, but for HER4 as well, HB-EGF binds to NIH 3T3 cells overexpressing either HER1 or HER4 alone, but not HER2 or HER3 alone, Binding to HER4 is independent of HER1, The ability of HB-EGF to bind to two different receptors is in contrast toEGF which binds to HER1, but not to HER4, and heregulin-beta 1 which binds to HER4, but not to HER1. Besides binding, HB-EGF activates HER4, For example (i) it induces tyrosine phosphorylation of HER4 in cellsoverexpressing this receptor and of endogenous HER4 in MDA-MB-453 cells and astrocytes; (ii) it induces association of phosphatidylinositol3-kinase (PI3-K) activity with HER4; and (iii) it is a potent chemotactic factor for cells overexpressing HER4, Chemotaxis is inhibited by wortmannin, a PI3-K inhibitor, suggesting a possible role for PI3-K inmediating HB-EGF-stimulated chemotaxis, On the other hand, HB-EGF is not a mitogen for cells expressing HER4, in contrast to its ability tostimulate both chemotaxis and proliferation in cells expressing HER1,It was concluded that HER4 is a newly described receptor for HB-EGF and that HB-EGF can activate two EGF receptor subtypes, HER1 and HER4, but with different biological responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 21:20:26