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Titolo:
DIFFERENTIAL PATHOGENESIS OF LETHAL MOUSEPOX IN CONGENIC DBA 2 MICE IMPLICATES NATURAL-KILLER-CELL RECEPTOR-NKR-P1 IN NECROTIZING HEPATITISAND THE 5TH-COMPONENT OF COMPLEMENT IN RECRUITMENT OF CIRCULATING LEUKOCYTES TO SPLEEN/
Autore:
BROWNSTEIN DG; GRAS L;
Indirizzi:
YALE UNIV,SCH MED,COMPARAT MED SECT,POB 208016 NEW HAVEN CT 06520
Titolo Testata:
The American journal of pathology
fascicolo: 4, volume: 150, anno: 1997,
pagine: 1407 - 1420
SICI:
0002-9440(1997)150:4<1407:DPOLMI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENERALIZED VIRAL-INFECTION; ECTROMELIA VIRUS-INFECTION; T-CELLS; LISTERIA-MONOCYTOGENES; INNATELY RESISTANT; ADHESION MOLECULE; INDUCED MORTALITY; MOSCOW-STRAIN; GENE-COMPLEX; LIVER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
D.G. Brownstein e L. Gras, "DIFFERENTIAL PATHOGENESIS OF LETHAL MOUSEPOX IN CONGENIC DBA 2 MICE IMPLICATES NATURAL-KILLER-CELL RECEPTOR-NKR-P1 IN NECROTIZING HEPATITISAND THE 5TH-COMPONENT OF COMPLEMENT IN RECRUITMENT OF CIRCULATING LEUKOCYTES TO SPLEEN/", The American journal of pathology, 150(4), 1997, pp. 1407-1420

Abstract

Innate resistance of C57BL/6 (B6) mice to lethal mousepox is controlled by multiple genes. Previously, four resistance genes were localizedto specific subchromosomal regions and transferred onto a susceptibleDBA/2 (D2) background by serial backcrossing and intercrossing to produce congenic strains. Intraperitoneally inoculated ectromelia virus was uniformly lethal and achieved similar titers in BG and D2 mice but elicited differential responses in liver, spleen, and circulating blood leukocytes. The distribution of these response phenotypes in congenic strains linked control of phenotypes with specific subchromosomal regions. D2.R1 mice, which carried a differential segment of chromosome 6, exhibited a BG liver response and intermediate spleen and circulating leukocyte responses, D2.R2 and D2.R4 mice, which carried differential segments of chromosomes 2 and 1, respectively, exhibited a D2 liverresponse, a B6 spleen response, and an intermediate circulating leukocyte response, The localization of control of liver response phenotypes to chromosome 6 implicates cells that express natural killer (NK) cell receptor NKR-P1 alloantigens. The localization of control of spleenand circulating leukocyte responses to chromosomes 1, 2, and G implicates NK cells, the fifth component of complement, and a gene near the selectin gene complex in recruitment of circulating leukocytes to spleen.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:07:03