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Titolo:
THE EFFECT OF SPINAL GABA RECEPTOR AGONISTS ON TACTILE ALLODYNIA IN ASURGICALLY-INDUCED NEUROPATHIC PAIN MODEL IN THE RAT
Autore:
HWANG JH; YAKSH TL;
Indirizzi:
UNIV CALIF SAN DIEGO,DEPT ANESTHESIOL,9500 GILMAN DR LA JOLLA CA 92093 UNIV CALIF SAN DIEGO,DEPT ANESTHESIOL LA JOLLA CA 92093 UNIV ULSAN,DEPT ANESTHESIOL,ASAN MED CTR SEOUL SOUTH KOREA
Titolo Testata:
Pain
fascicolo: 1, volume: 70, anno: 1997,
pagine: 15 - 22
SICI:
0304-3959(1997)70:1<15:TEOSGR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY AMINO-ACIDS; SCIATIC-NERVE INJURY; DORSAL-ROOT GANGLIA; PERIPHERAL NEUROPATHY; SENSORY NEURONS; TRANSSYNAPTIC DEGENERATION; SPONTANEOUS DISCHARGE; EVOKED ALLODYNIA; CORD ISCHEMIA; BACLOFEN;
Keywords:
NEUROPATHIC PAIN; CHUNG MODEL; ALLODYNIA; GABA RECEPTOR; BACLOFEN; MUSCIMOL; INTRATHECAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
J.H. Hwang e T.L. Yaksh, "THE EFFECT OF SPINAL GABA RECEPTOR AGONISTS ON TACTILE ALLODYNIA IN ASURGICALLY-INDUCED NEUROPATHIC PAIN MODEL IN THE RAT", Pain, 70(1), 1997, pp. 15-22

Abstract

This study evaluated the effects of spinal gamma-aminobutyric acid (GABA) receptor agonists on the tactile allodynia observed in rats with ligation of the L5/L6 nerve roots (Chung model) and chronic lumbar intrathecal catheters. In these rats, the spinal injection of the GABAB agonist baclofen (BAG; 0.03-0.3 mu g) and GABAA agonist muscimol (MUS; 0.1-1.0 mu g) resulted in a dose-dependent antagonism of the allodyniaat doses which had no detectable effect upon motor function. Intrathecal injection of the GABAB antagonist CGP 35348 (CGP; 30 mu g) or the GABAA antagonist bicuculline (BIC; 0.3 mu g) prior to injection of each GABA receptor agonist had little effect upon normal or tactile allodynic thresholds, but significantly reversed the anti-allodynic effectsproduced by the respective receptor agonists. The antagonistic effects were limited to the agonist of the respective receptor. These observations indicate that spinal GABAA and GABAB receptors modulate spinal systems activated by low threshold mechanoreceptors which mediate the allodynia observed following peripheral nerve injury. (C) 1997 International Association for the Study of Pain.

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Documento generato il 05/12/20 alle ore 01:41:11