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Titolo:
EVALUATING NEOADJUVANT THERAPY EFFECTIVENESS ON SYSTEMIC-DISEASE - USE OF A PROSTATIC-SPECIFIC MEMBRANE REVERSE TRANSCRIPTION-POLYMERASE CHAIN-REACTION
Autore:
SU SL; HESTON WDW; PERROTI M; COOKSON MS; STROUMBAKIS N; HUYRK R; EDWARDS E; BRANDER B; COKE J; SOLOWAY S; LEWIS A; FAIR WR;
Indirizzi:
MEM SLOAN KETTERING CANC CTR,DEPT SURG,UROL SERV,1275 YORK AVE NEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR,DEPT SURG,UROL SERV NEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR,GEORGE M OBRIEN UROL RES CTR PROSTATE CANC NEW YORK NY 10021
Titolo Testata:
Urology
fascicolo: 3A, volume: 49, anno: 1997, supplemento:, S
pagine: 95 - 101
SICI:
0090-4295(1997)49:3A<95:ENTEOS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIRCULATING TUMOR-CELLS; RADICAL PROSTATECTOMY; SENSITIVE DETECTION; PERIPHERAL-BLOOD; REACTION ASSAY; BONE-MARROW; HEMATOGENOUS DISSEMINATION; MELANOMA-CELLS; BREAST-CANCER; LYMPH-NODES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
S.L. Su et al., "EVALUATING NEOADJUVANT THERAPY EFFECTIVENESS ON SYSTEMIC-DISEASE - USE OF A PROSTATIC-SPECIFIC MEMBRANE REVERSE TRANSCRIPTION-POLYMERASE CHAIN-REACTION", Urology, 49(3A), 1997, pp. 95-101

Abstract

Objective. An on-going study at the Memorial Sloan-Kettering Cancer Center assessed the effectiveness of androgen deprivation therapy (ADT)prior to surgical removal of the prostate. In this report, we evaluate the effectiveness of ADT on systemic disease by monitoring the presence or absence of circulating prostatic epithelial cells using a reverse transcription polymerase chain reaction (RT-PCR) assay for prostatic-specific membrane antigen (PSM). Methods. PSM RT-PCR was performed on a total of 38 prostate cancer patients. There were 12 pT2 patients in the ADT group and 10 patients in the control pT2 group and 5 pT3 patients in the ADT group and 11 pT3 patients in the control group. Results. For pT2 patients, 2 of the 12 patients (17%) were positive for circulating prostatic cells during androgen deprivation therapy but before radical retroprostatectomy (RRP). Within a 6-month period after RRP,3 of 12 patients (25%) were positive. For the period between the 7th and 12th month after RRP, 6 of 12 patients (50%) were positive. For the period 12-36 months after RRP, 2 of the 12 patients (17%) remained positive for circulating prostatic cells. In contrast, the pT2 control group had higher positive rates in comparable periods: 4 of 10 patients (40%) were positive prior to surgery; 6 of 10 patients (60%) were positive during the 6 months following surgery. For the period between the 7th and 12th month following surgery, 4 of 7 patients (57%) were positive for PSM. Finally, 3 of 6 patients (50%) were positive for the period longer than 12 months. Regarding patients who have extraprostatic disease (stage pT3), the ADT group had a lower rate of circulating PSM positive cells. Before RRP and during androgen deprivation therapy,1 out of 5 patients (20%) in the ADT group were positive as compared to 4 out of I 1 patients for the control group. Within a 6-month period after RRP, the ADT group had 4 out of 9 (44%) patients positive for PSM as compared to 9 of 11 (82%) for the control group. For the periodbetween the 7th and 12th months postsurgery, 1 of 5 patients (20%) ofthe ADT group were positive as compared to 4 of 7 (57%) of the control patients. Conclusions. These results indicate that patients with pT2and pT3 lesions who receive neoadjuvant ADT are less likely to have circulating tumor cells detected compared to a control group both priorto and after surgery. In addition, irrespective of ADT or control group, there were increases in the detection of circulating tumor cells in the period after RRP, and this rise gradually decreased, suggesting that surgical manipulation may cause hematogenous dissemination of tumor cells and that ADT reduces such dissemination of tumor cells. Overall, these results indicate that the use of neoadjuvant ADT decreases the number of circulating prostatic cells. These data represent the initial results of an on-going study. As additional patients are added tothe studies, attempts to correlate PSM positivity and serum PSA values postoperatively, recurrence, and margin positivity will be made. (C)1997 by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:38:25