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Titolo:
DESTRUCTION OF CENTRAL NORADRENERGIC NEURONS WITH DSP4 IMPAIRS THE ACQUISITION OF TEMPORAL DISCRIMINATION BUT DOES NOT AFFECT MEMORY FOR DURATION IN A DELAYED CONDITIONAL DISCRIMINATION TASK
Autore:
ALZAHRANI SSA; ALRUWAITEA ASA; HO MY; BRADSHAW CM; SZABADI E;
Indirizzi:
UNIV NOTTINGHAM,DEPT PSYCHIAT,QUEENS MED CTR NOTTINGHAM NG7 2UH ENGLAND UNIV NOTTINGHAM,DEPT PSYCHIAT,QUEENS MED CTR NOTTINGHAM NG7 2UH ENGLAND
Titolo Testata:
Psychopharmacology
fascicolo: 2, volume: 130, anno: 1997,
pagine: 166 - 173
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS BASALIS MAGNOCELLULARIS; NORADRENALINE RELEASE; OPERANT-BEHAVIOR; LOCUS COERULEUS; 5-HYDROXYTRYPTAMINERGIC NEURONS; POSITIVE REINFORCEMENT; RECEPTOR ACTIVATION; SELECTIVE ATTENTION; RAT HIPPOCAMPUS; PIGEONS MEMORY;
Keywords:
NORADRENALINE; DSP4; OPERANT BEHAVIOR; LEARNING; TIME DISCRIMINATION; MEMORY FOR DURATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
S.S.A. Alzahrani et al., "DESTRUCTION OF CENTRAL NORADRENERGIC NEURONS WITH DSP4 IMPAIRS THE ACQUISITION OF TEMPORAL DISCRIMINATION BUT DOES NOT AFFECT MEMORY FOR DURATION IN A DELAYED CONDITIONAL DISCRIMINATION TASK", Psychopharmacology, 130(2), 1997, pp. 166-173

Abstract

This experiment examined the effect of destroying central noradrenergic neurones using the selective neurotoxin N-(2-chloroethyl)-n-ethyl-2-bromobenzylamine (DSP4) on the acquisition of a temporal discrimination and on memory for duration, using a delayed conditional discrimination task. In phase I, rats that had received systemic treatment with DSP4 and vehicle-treated control rats were trained in a series of discrete trials to press lever A following a 2-s presentation of a light stimulus, and lever B following an 8-s presentation of the same stimulus. Following stimulus offset, a response on a panel placed midway between the two levers was required to initiate lever presentation; a single response on either lever resulted in withdrawal of both levers and, in the case of a ''correct'' response. reinforcer delivery. Both groups acquired accurate discrimination. achieving 90% correct choices within 50 sessions; the DSP4-treated group acquired accurate performance more slowly than the control group. In phase II, delays were interposedbetween stimulus offset and lever presentation in 50% of the trials. In the absence of a delay, discriminative accuracy was lower in the DSP4-treated group than in the control group. Accuracy declined as a function of post-stimulus delay in both groups; both groups showed a delay-dependent bias towards responding on lever A (''choose-short'' bias). Neither of these effects differed significantly between the two groups. The concentrations of noradrenaline in the parietal cortex and hippocampus were reduced by 90% and 89% in the DSP4-treated group, compared to the levels in the control group, but the levels of dopamine, 5-hydroxytryptamine and 5-hydroxyindoleacetic acid did not differ significantly between the groups. The results confirm the deleterious effect of DSP4 on the acquisition of temporal discrimination, but do not provide evidence for a role of the noradrenergic innervation of the hippocampus and neocortex in temporal working memory.

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Documento generato il 03/04/20 alle ore 07:56:18