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Titolo:
DIFFERENTIAL EXPRESSION OF TISSUE-SPECIFIC ADHESION MOLECULES ON HUMAN CIRCULATING ANTIBODY-FORMING-CELLS AFTER SYSTEMIC, ENTERIC, AND NASAL IMMUNIZATIONS - A MOLECULAR-BASIS FOR THE COMPARTMENTALIZATION OF EFFECTOR B-CELL RESPONSES
Autore:
QUIDINGJARBRINK M; NORDSTROM I; GRANSTROM G; KILANDER A; JERTBORN M; BUTCHER EC; LAZAROVITS AI; HOLMGREN J; CZERKINSKY C;
Indirizzi:
GOTHENBURG UNIV,DEPT MED MICROBIOL & IMMUNOL,GULDHEDSGATAN 10A S-41346 GOTHENBURG SWEDEN GOTHENBURG UNIV,DEPT MED MICROBIOL & IMMUNOL S-41346 GOTHENBURG SWEDEN SAHLGRENS UNIV HOSP,DEPT OTORHINOLARYNGOL S-41346 GOTHENBURG SWEDEN SAHLGRENS UNIV HOSP,DEPT INTERNAL MED S-41346 GOTHENBURG SWEDEN STANFORD UNIV,DIGEST DIS CTR STANFORD CA 94305 STANFORD UNIV,DEPT PATHOL STANFORD CA 94305 UNIV WESTERN ONTARIO,UNIV HOSP,ROBARTS RES INST LONDON ON N6A 5A5 CANADA HOP EDOUARD HERRIOT,INSERM F-69437 LYON FRANCE
Titolo Testata:
The Journal of clinical investigation
fascicolo: 6, volume: 99, anno: 1997,
pagine: 1281 - 1286
SICI:
0021-9738(1997)99:6<1281:DEOTAM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORAL CHOLERA VACCINATION; MUCOSAL IMMUNE-SYSTEM; PERIPHERAL-BLOOD; LYMPH-NODES; HOMING RECEPTORS; IMMUNOGLOBULIN-A; HIGH ENDOTHELIUM; SECRETING CELLS; HUMAN TONSILS; ANTIGEN;
Keywords:
CELL TRAFFICKING; ANTIBODY-FORMING CELLS; ADHESION MOLECULE; HUMAN MUCOSA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
M. Quidingjarbrink et al., "DIFFERENTIAL EXPRESSION OF TISSUE-SPECIFIC ADHESION MOLECULES ON HUMAN CIRCULATING ANTIBODY-FORMING-CELLS AFTER SYSTEMIC, ENTERIC, AND NASAL IMMUNIZATIONS - A MOLECULAR-BASIS FOR THE COMPARTMENTALIZATION OF EFFECTOR B-CELL RESPONSES", The Journal of clinical investigation, 99(6), 1997, pp. 1281-1286

Abstract

Expression of the adhesion molecules CD44, L-selectin (CD62L), and integrin alpha 4 beta 7 by antibody-secreting cells (ASC) was examined in human volunteers after oral, rectal, intranasal, or systemic immunization with cholera toxin B subunit. Almost all blood ASC, irrespectiveof immunization route, isotype (IgG and IgA), and immunogen, expressed CD44. On the other hand, marked differences were observed between systemically and intestinally induced ASC with respect to expression of integrin alpha 4 beta 7 and L-selectin, adhesion molecules conferring tissue specificity for mucosal tissues and peripheral lymph nodes, respectively. Thus, most ASC induced at systemic sites expressed L-selectin, whereas only a smaller proportion of ASC expressed alpha 4 beta 7. In contrast, virtually all IgA- and even IgG-ASC detected after peroral and rectal immunizations expressed alpha 4 beta 7, with only a minor fraction of these cells expressing L-selectin. Circulating ASC induced by intranasal immunization displayed a more promiscuous pattern of adhesion molecules, with a large majority of ASC coexpressing L-selectin and alpha 4 beta 7. These results demonstrate that circulating ASC induced by mucosal and systemic immunization express different sets ofadhesion molecules. Furthermore, these findings provide for the firsttime evidence for differential expression of adhesion molecules on circulating ASC originating from different mucosal sites. Collectively, these results may explain the anatomical division of mucosal and systemic immune responses in humans as well as the compartmentalization of mucosal immune responses initiated in the upper vs. the lower aerodigestive tract.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:20:43