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Titolo:
IMMUNOCYTOCHEMICAL LOCALIZATION OF THE GABA(C) RECEPTOR RHO-SUBUNIT IN THE CAT, GOLDFISH, AND CHICKEN RETINA
Autore:
KOULEN P; BRANDSTATTER JH; KROGER S; ENZ R; BORMANN J; WASSLE H;
Indirizzi:
MAX PLANCK INST HIRNFORSCH,DEUTSCHORDENSTR 46 D-60528 FRANKFURT GERMANY MAX PLANCK INST HIRNFORSCH D-60528 FRANKFURT GERMANY
Titolo Testata:
Journal of comparative neurology
fascicolo: 4, volume: 380, anno: 1997,
pagine: 520 - 532
SICI:
0021-9967(1997)380:4<520:ILOTGR>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; ROD BIPOLAR CELLS; PROTEIN-KINASE-C; INNER PLEXIFORM LAYER; RAT CEREBELLAR MEMBRANES; TIGER SALAMANDER RETINA; IN-SITU HYBRIDIZATION; MACAQUE MONKEY RETINA; A-RECEPTOR; MAMMALIAN RETINA;
Keywords:
RECEPTOR; BIPOLAR CELLS; PKC IMMUNOSTAINING;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
105
Recensione:
Indirizzi per estratti:
Citazione:
P. Koulen et al., "IMMUNOCYTOCHEMICAL LOCALIZATION OF THE GABA(C) RECEPTOR RHO-SUBUNIT IN THE CAT, GOLDFISH, AND CHICKEN RETINA", Journal of comparative neurology, 380(4), 1997, pp. 520-532

Abstract

Polyclonal antibodies against the N-terminus of the rat pi subunit were used to study the distribution of gamma-aminobutyric acid C (GABA(C)) receptors in the cat, goldfish, and chicken retina. Strong punctateimmunoreactivity was present in the inner plexiform layer (IPL) of all three species. The punctate labelling suggests a clustering of the GABA(C) receptors at synaptic sites. Weak label was also found in the outer plexiform layer (OPL) and over the cell bodies of bipolar cells. Double immunostaining of vertical sections with an antibody against protein kinase C (PKC) showed the punctate immunofluorescence to colocalize with bipolar cell axon terminals. In the goldfish retina, the axonterminals of Mb1 bipolar cells were enclosed by rho-immunoreactive puncta. In the chicken retina, several distinct strata within the IPL showed a high density of rho-immunoreactive puncta. The results suggest a high degree of sequence homology between the rho subunits of different vertebrate species, and they show that the retinal localization of GABA(C) receptors is similar across different species. (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 23:54:01