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Titolo:
CORONARY FLOW AND CORONARY FLOW RESERVE MEASUREMENTS IN HUMANS WITH BREATH-HELD MAGNETIC-RESONANCE PHASE-CONTRAST VELOCITY MAPPING
Autore:
DAVIS CP; LIU PF; HAUSER M; GOHDE SC; VONSCHULTHESS GK; DEBATIN JF;
Indirizzi:
UNIV ZURICH HOSP,DEPT DIAGNOST RADIOL,MRI CTR,RAMISTR 100 CH-8091 ZURICH SWITZERLAND UNIV ZURICH HOSP,DEPT DIAGNOST RADIOL,MRI CTR CH-8091 ZURICH SWITZERLAND
Titolo Testata:
Magnetic resonance in medicine
fascicolo: 4, volume: 37, anno: 1997,
pagine: 537 - 544
SICI:
0740-3194(1997)37:4<537:CFACFR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOLD MR-ANGIOGRAPHY; BLOOD-FLOW; ARTERY DISEASE; PHYSIOLOGIC SIGNIFICANCE; MEDIATED DILATION; CONSCIOUS DOGS; IN-VIVO; ATHEROSCLEROSIS; QUANTITATION; LESIONS;
Keywords:
CORONARY ARTERIES; CORONARY FLOW MEASUREMENTS; PHASE CONTRAST MRI; FLOW QUANTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
C.P. Davis et al., "CORONARY FLOW AND CORONARY FLOW RESERVE MEASUREMENTS IN HUMANS WITH BREATH-HELD MAGNETIC-RESONANCE PHASE-CONTRAST VELOCITY MAPPING", Magnetic resonance in medicine, 37(4), 1997, pp. 537-544

Abstract

Objective evidence for coronary lesion significance can be obtained with ischemic stress testing, Since flow-limiting stenoses have alreadyundergone compensatory vasodilatation to maintain flow, the response to vasoactive stimulation is dampened. The degree of response limitation is reflected by the coronary flow reserve (CFR), Absolute volume flow rates can be accurately and noninvasively measured with MRI techniques, The purpose was to assess the ability to measure coronary volume flow rate noninvasively, and characterize the effect of pharmacologic stress on coronary flow quantitatively by using ultrafast, breath-heldsegmented k-space phase-contrast-MR imaging (PC-MRI), Ten healthy volunteers were examined by using ultrafast breath-held PC-MRI. Coronary volume flow rates were measured in the anterior descending coronary artery (LAD) at rest and following intravenous administration of dipyridamole. CFR was determined based on these data. Mean LAD volume flow rates increased from 38 +/- 11 ml/min before application of dipyridamoleto 169 +/- 42 ml/min, The mean CFR amounted to 5.0 +/- 2.6 (median = 4.15). This study demonstrates the feasibility of breath-held PC-MRI to noninvasively quantify coronary volume flow rates over the cardiac cycle, Pharmacologically induced changes in volume flow rate and thus CFR can be quantitated.

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Documento generato il 26/09/20 alle ore 07:52:35