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Titolo:
BILIODIGESTIVE SHUNT EVOKES HYPERCCKEMIA AND TROPHIC EFFECTS IN THE RAT PANCREAS, BUT NOT IN THE LIVER OR GASTROINTESTINAL-TRACT
Autore:
OHLSSON B; JANSEN C; REHFELD JF; STERNBY B; IHSE I; AXELSON J;
Indirizzi:
UNIV LUND HOSP,DEPT SURG S-22185 LUND SWEDEN RIGSHOSP,DEPT CLIN BIOCHEM COPENHAGEN DENMARK
Titolo Testata:
Pancreas
fascicolo: 3, volume: 14, anno: 1997,
pagine: 255 - 261
SICI:
0885-3177(1997)14:3<255:BSEHAT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEGATIVE FEEDBACK-CONTROL; EPIDERMAL GROWTH-FACTOR; PANCREATICOBILIARY DIVERSION; CHOLECYSTOKININ RELEASE; BILE-ACIDS; PLASMA CHOLECYSTOKININ; INTRADUODENAL BILE; CONSCIOUS RATS; SECRETION; INHIBITION;
Keywords:
BILIODIGESTIVE; LIVER; GASTROINTESTINAL TRACT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
B. Ohlsson et al., "BILIODIGESTIVE SHUNT EVOKES HYPERCCKEMIA AND TROPHIC EFFECTS IN THE RAT PANCREAS, BUT NOT IN THE LIVER OR GASTROINTESTINAL-TRACT", Pancreas, 14(3), 1997, pp. 255-261

Abstract

The influence of bile on the release of cholecystokinin (CCK) and, thereby, on the regulation of exocrine pancreatic function and growth isunsettled. The aim of this study was to elucidate the effect of long-term diversion of bile from the upper small intestine on CCK release and on the pancreas, liver, and gastrointestinal tract. A surgical biliodigestive shunt was performed in rats, diverting the bile flow directly to the middle of the small intestine. The animals were killed after4 or 12 weeks. Plasma CCK and trophic effects on the pancreas, liver,and gastrointestinal tract were determined, as were the trypsin and chymotrypsin contents in the intestine. The CCK concentration in plasmaincreased 10-fold at both time points studied. The pancreas doubled its weight from 4 weeks onward. Also, pancreatic protein, DNA, and amylase contents were increased throughout the study. The liver and gastrointestinal tract were unaffected. Intraluminal bile plays a role in the feedback regulation of CCK release and is involved in this way in the control of pancreatic growth but has no similar effects on the liveror gastrointestinal tract.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 16:40:49