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Titolo:
GATA-4 ACTIVATES TRANSCRIPTION VIA 2 NOVEL DOMAINS THAT ARE CONSERVEDWITHIN THE GATA-4 5/6 SUBFAMILY/
Autore:
MORRISEY EE; IP HS; TANG ZH; PARMACEK MS;
Indirizzi:
UNIV CHICAGO,DEPT MED,5841 S MARYLAND AVE,MC 6088 CHICAGO IL 60637 UNIV CHICAGO,DEPT MED CHICAGO IL 60637
Titolo Testata:
The Journal of biological chemistry
fascicolo: 13, volume: 272, anno: 1997,
pagine: 8515 - 8524
SICI:
0021-9258(1997)272:13<8515:GATV2N>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENHANCER-BINDING FACTOR; SERUM RESPONSE FACTOR; HEAVY-CHAIN GENE; TROPONIN-C GENE; DNA-BINDING; ENDOTHELIAL-CELLS; DEVELOPING HEART; MAMMALIAN-CELLS; SKELETAL-MUSCLE; CARDIAC DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
E.E. Morrisey et al., "GATA-4 ACTIVATES TRANSCRIPTION VIA 2 NOVEL DOMAINS THAT ARE CONSERVEDWITHIN THE GATA-4 5/6 SUBFAMILY/", The Journal of biological chemistry, 272(13), 1997, pp. 8515-8524

Abstract

GATA-4 is one of the earliest developmental markers of the precardiacmesoderm, heart, and gut and has been shown to activate regulatory elements controlling transcription of genes encoding cardiac-specific proteins, To elucidate the molecular mechanisms underlying the transcriptional activity of the GATA-4 protein, structure-function analyses were performed. These analyses revealed that the C-terminal zinc finger and adjacent basic domain of GATA-4 is bifunctional, modulating both DNA-binding and nuclear localization activities, The N terminus of the protein encodes two independent transcriptional Activation Domains (amino acids 1-74 and amino acids 130-177). Amino acid residues were identified within each domain that are required for transcriptional activation, Finally, we have shown that regions of Xenopus GATA-5 and -6 corresponding to Activation Domains I and II, respectively, function as potent transcriptional activators. The identification and functional characterization of two evolutionarily conserved transcriptional Activation Domains within the GATA-4/5/6 subfamily suggests that each of thesedomains modulates critical functions in the transcriptional regulatory program(s) encoded by GATA-4, -5, and -6 during vertebrate development. As such these data provide novel insights into the molecular mechanisms that control development of the heart.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:26:24