Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
BIOSYNTHESIS OF ALPHA(1)-PROTEINASE INHIBITOR BY HUMAN LUNG-DERIVED EPITHELIAL-CELLS
Autore:
CICHY J; POTEMPA J; TRAVIS J;
Indirizzi:
UNIV GEORGIA,DEPT BIOCHEM & MOL BIOL ATHENS GA 30602 UNIV GEORGIA,DEPT BIOCHEM & MOL BIOL ATHENS GA 30602 JAGIELLONIAN UNIV,INST MOL BIOL,DEPT MICROBIOL & IMMUNOL PL-31120 KRAKOW POLAND
Titolo Testata:
The Journal of biological chemistry
fascicolo: 13, volume: 272, anno: 1997,
pagine: 8250 - 8255
SICI:
0021-9258(1997)272:13<8250:BOAIBH>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE-PHASE RESPONSE; ONCOSTATIN-M; AFFINITY ELECTROPHORESIS; PROTEINS; ALPHA-1-ANTITRYPSIN; GLYCOSYLATION; EMPHYSEMA; RECEPTOR; CDNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
J. Cichy et al., "BIOSYNTHESIS OF ALPHA(1)-PROTEINASE INHIBITOR BY HUMAN LUNG-DERIVED EPITHELIAL-CELLS", The Journal of biological chemistry, 272(13), 1997, pp. 8250-8255

Abstract

Destruction of components of the extracellular matrix of the lung by neutrophil elastase is believed to be a critical event in the development of obstructive lung disease. The local synthesis of alpha(1)-proteinase inhibitor, the controlling inhibitor of this enzyme, may providea partial mechanism for neutrophil elastase regulation, especially during inflammation, when proteolytic enzymes are released from phagocytes. In this study, we show that lung-derived epithelial cells not onlyhave the capacity to synthesize functional alpha(1)-PI but also to increase the rate of its production when stimulated by specific inflammatory mediators, including oncostatin M, interleukin-1, and the glucocorticoid analogue, dexamethasone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 00:55:42