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Titolo:
THE EFFECTS OF REVERSIBLE INACTIVATION OF THE SUBTHALAMOPALLIDAL PATHWAY ON THE BEHAVIOR OF NAIVE AND HEMIPARKINSONIAN MONKEYS
Autore:
BUTLER EG; BOURKE DW; FINKELSTEIN DI; HORNE MK;
Indirizzi:
MONASH MED CTR,DEPT NEUROSCI CLAYTON VIC 3168 AUSTRALIA MONASH UNIV,DEPT ANAT CLAYTON VIC 3168 AUSTRALIA
Titolo Testata:
Journal of clinical neuroscience
fascicolo: 2, volume: 4, anno: 1997,
pagine: 218 - 227
SICI:
0967-5868(1997)4:2<218:TEORIO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMATE SUBTHALAMIC NUCLEUS; EXCITOTOXIC ACID LESIONS; NEURONAL-ACTIVITY; GLOBUS-PALLIDUS; BASAL GANGLIA; MOTOR CORTEX; INDUCED DYSKINESIA; NEURAL MECHANISMS; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MPTP; VENTROLATERAL THALAMUS;
Keywords:
PARKINSONISM; DYSTONIA; SUBTHALAMIC NUCLEUS; MUSCIMOL; GLOBUS PALLIDUS; KYNURENIC ACID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
67
Recensione:
Indirizzi per estratti:
Citazione:
E.G. Butler et al., "THE EFFECTS OF REVERSIBLE INACTIVATION OF THE SUBTHALAMOPALLIDAL PATHWAY ON THE BEHAVIOR OF NAIVE AND HEMIPARKINSONIAN MONKEYS", Journal of clinical neuroscience, 4(2), 1997, pp. 218-227

Abstract

This study was designed to further investigate the role of the subthalamic nucleus (STN) and globus pallidus internus (GPI) in the pathophysiology of Parkinson's disease. The prevailing theory about the pathophysiology of Parkinson's disease (PD) predicts that there is overactivity of the subthalamo-pallidal pathway. In order to inactivate that pathway naive and hemiparkinsonian monkeys were locally administered either muscimol (to reversibly inactivate the contralateral STN) or kynurenic acid (to reduce glutamatergic activity in the contralateral GPi). Three naive and 2 hemiparkinsonian monkeys were studied. Intra-carotid MPTP was administered to produce 2 hemiparkinsonian monkeys. injection sites of muscimol and kynurenic acid in the brain were confirmed electrophysiologically and histologically. injections of muscimol into the STN in naive and hemiparkinsonian monkeys caused reversible contralateral dystonia, but did not alleviate Parkinsonism. Only one kynuremic acid injection into GPi partially alleviated Parkinsonism. On the basis of the results in this study, aspects of the currently accepted hypothesis of the pathophysiology of PD cannot be confirmed. However, this study reports that the STN has an important role in the production of dystonia. This experimental model of dystonia will prove suitable for further study of both the mechanisms causing dystonia as well as for possible therapeutic approaches to its treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:25:15