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Titolo:
HISTOPATHOLOGY OF PRIMARY BILIARY-CIRRHOSIS WITH EMPHASIS ON EXPRESSION OF ADHESION MOLECULES
Autore:
NAKANUMA Y; YASOSHIMA M; TSUNEYAMA K; HARADA K;
Indirizzi:
KANAZAWA UNIV,SCH MED,DEPT PATHOL 2 KANAZAWA ISHIKAWA 920 JAPAN
Titolo Testata:
Seminars in liver disease
fascicolo: 1, volume: 17, anno: 1997,
pagine: 35 - 47
SICI:
0272-8087(1997)17:1<35:HOPBWE>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC HEPATITIS-C; BILE-DUCT CELLS; PRIMARY SCLEROSING CHOLANGITIS; URSODEOXYCHOLIC ACID THERAPY; CHRONIC LIVER-DISEASES; HEPATOBILIARY DISEASES; HLA-DR; LEUKOCYTE ADHESION; E-SELECTIN; RECEPTOR;
Keywords:
INTERCELLULAR ADHESION MOLECULES 1; VASCULAR ADHESION MOLECULE 1; VERY LATE ANTIGEN FAMILY; B-7 FAMILY; EPITHELIOTROPISM;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
75
Recensione:
Indirizzi per estratti:
Citazione:
Y. Nakanuma et al., "HISTOPATHOLOGY OF PRIMARY BILIARY-CIRRHOSIS WITH EMPHASIS ON EXPRESSION OF ADHESION MOLECULES", Seminars in liver disease, 17(1), 1997, pp. 35-47

Abstract

In the initiation and progression of immune-mediated destruction of interlobular bile ducts and hepatocytes in primary biliary cirrhosis, T-cell-mediated responses to target antigen(s) expressed on the bile ducts and hepatocytes, as well as cellular adhesions via various adhesion molecules are critical. Intercellular adhesion molecule 1 and, to a lesser degree, vascular adhesion molecule 1 are increasingly expressedon the damaged bile ducts in primary biliary cirrhosis. In addition, lymphocyte function-associated antigens, very late antigens, endothelial-leukocyte adhesion molecule I, and other adhesion molecules on the vascular endothelial cells and/or inflammatory cells, particularly activated lymphocytes, are also expressed in the portal tracts and hepatic parenchyma. These adhesion molecules are involved in the extravasation as well as epitheliotropic processes of inflammatory cells. Dendritic cells, particularly interdigitating ones in the periductal tissue, are positive for these immune molecules and also for the B-7 family. They may also be important in antigen presentation to CD4+ helper T cells and their activation. However; there is still controversy about whether the B-7 family is expressed on the bile ducts and, then, whether biliary epithelial cells work as an antigen presenting cell. Expression of a very late antigen family on the basolateral surface of bile ducts may be involved in the cell-cell and cell-matrix interactions. Soluble adhesion molecules may be involved in the regulation of immune-mediated bile duct lesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:36:16