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Titolo:
LYMPHOCYTIC AND GRANULOMATOUS HYPOPHYSITIS - EXPERIENCE WITH 9 CASES
Autore:
HONEGGER J; FAHLBUSCH R; BORNEMANN A; HENSEN J; BUCHFELDER M; MULLER M; NOMIKOS P;
Indirizzi:
UNIV ERLANGEN NURNBERG,DEPT NEUROSURG,SCHWABACHANLAGE 6 D-91054 ERLANGEN GERMANY UNIV ERLANGEN NURNBERG,INST PATHOL D-91054 ERLANGEN GERMANY UNIV ERLANGEN NURNBERG,DEPT MED D-91054 ERLANGEN GERMANY
Titolo Testata:
Neurosurgery
fascicolo: 4, volume: 40, anno: 1997,
pagine: 713 - 722
SICI:
0148-396X(1997)40:4<713:LAGH-E>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIABETES-INSIPIDUS; CAVERNOUS SINUS; ADENOHYPOPHYSITIS; PITUITARY; HYPOPITUITARISM; PREGNANCY; ENTITY; MASS; INVOLVEMENT;
Keywords:
GRANULOMATOUS HYPOPHYSITIS; LYMPHOCYTIC HYPOPHYSITIS; PITUITARY SURGERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
J. Honegger et al., "LYMPHOCYTIC AND GRANULOMATOUS HYPOPHYSITIS - EXPERIENCE WITH 9 CASES", Neurosurgery, 40(4), 1997, pp. 713-722

Abstract

OBJECTlVE: Lymphocytic hypophysitis and granulomatous hypophysitis are rarely encountered. The aim of this study was to demonstrate their clinical peculiarities among pituitary disorders and to provide an approach for their clinical management. METHODS: In a retrospective study,we reviewed our surgical experience with nine patients harboring hypophysitis. The series included six cases of lymphocytic hypophysitis, two cases of granulomatous hypophysitis, and one case with evidence of coexisting lymphocytic and granulomatous hypophysitis. RESULTS: A striking similarity of clinical signs was found for our nine patients. Headache or aseptic meningitis, thickening of the sphenoid sinus mucosa, pituitary stalk enlargement, and tongue-shaped extension of the lesionalong the basal hypothalamus were characteristic signs. Lymphocytic hypophysitis was not associated with pregnancy in any of the seven cases. No recurrence has been observed in six cases with total removal of the inflammatory tissue. CONCLUSION: Lymphocytic hypophysitis and granulomatous hypophysitis represent related inflammatory disorders. Theirconspicuous clinical features frequently allow preoperative diagnosisof hypophysitis. In view of their sometimes insidious clinical course, early surgical exploration is justified.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 07:00:29