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Titolo:
EARLY POSTNATAL DEXAMETHASONE THERAPY MAY LESSEN LUNG INFLAMMATION INPREMATURE-INFANTS WITH RESPIRATORY-DISTRESS SYNDROME ON MECHANICAL VENTILATION
Autore:
WANG JY; YEH TF; LIN YJ; CHEN WY; LIN CH;
Indirizzi:
NATL CHENG KUNG UNIV,COLL MED,DEPT PEDIAT,NEONATAL & PERINATAL RES CTR,138 SHENG LI RD TAINAN 70428 TAIWAN NATL CHENG KUNG UNIV,COLL MED,DEPT PEDIAT,NEONATAL & PERINATAL RES CTR TAINAN 70428 TAIWAN KAO HSIUNG MED COLL,DEPT PEDIAT KAOHSIUNG TAIWAN
Titolo Testata:
Pediatric pulmonology
fascicolo: 3, volume: 23, anno: 1997,
pagine: 193 - 197
SICI:
8755-6863(1997)23:3<193:EPDTML>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHOPULMONARY DYSPLASIA; OXYGEN-TOXICITY; ALPHA-1-PROTEINASE INHIBITOR; PULMONARY INFLAMMATION; CONTROLLED TRIAL; CORTICOSTEROIDS; ELASTASE; PATHOGENESIS; PREVENTION; DISEASE;
Keywords:
DEXAMETHASONE; BRONCHOPULMONARY DYSPLASIA; 6-KETO-PGF(1-ALPHA); LEUKOTRIENE B-4; RESPIRATORY DISTRESS SYNDROME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
J.Y. Wang et al., "EARLY POSTNATAL DEXAMETHASONE THERAPY MAY LESSEN LUNG INFLAMMATION INPREMATURE-INFANTS WITH RESPIRATORY-DISTRESS SYNDROME ON MECHANICAL VENTILATION", Pediatric pulmonology, 23(3), 1997, pp. 193-197

Abstract

Early postnatal use of dexamethasone has recently been shown to be effective in improving the pulmonary status in premature infants with respiratory distress syndrome (RDS). To study the effect of dexamethasone on pulmonary inflammatory responses, we studied ten infants treated with dexamethasone and ten infants without this treatment. Serial tracheal aspirates were obtained for cell counts, neutrophil counts, totalprotein concentrations, and leukotriene B-4 (LTB(4)) and 6-keto prostaglandin (PG)F-1 alpha levels before and after starting the study. Infants in the dexamethasone-treated group required significantly lower mean airway pressures for ventilation and had lower PaCO2 values from day 3 to day 14 than infants in the control group, suggesting better pulmonary function. For infants in the dexamethasone group, the trachealaspirates showed significantly lower cell and neutrophil counts, protein concentrations, and 6-keto-PGF(1 alpha) and LTB(4) levels than in the control group. We conclude that early postnatal dexamethasone therapy may lessen lung inflammation and improve pulmonary function in infants with RDS. (C) Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 09:15:43