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Titolo:
CELL-ADHESION MOLECULES AND THE TRANSITION FROM SHORT-TERM-MEMORY TO LONG-TERM-MEMORY
Autore:
ROSE SPR;
Indirizzi:
OPEN UNIV,DEPT BIOL,BRAIN RES GRP MILTON KEYNES MK7 6AA BUCKS ENGLAND
Titolo Testata:
JOURNAL OF PHYSIOLOGY-PARIS
fascicolo: 5-6, volume: 90, anno: 1996,
pagine: 387 - 391
SICI:
0928-4257(1996)90:5-6<387:CMATTF>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PASSIVE-AVOIDANCE TASK; DAY-OLD CHICKS; N-CAM; GLYCOPROTEIN-SYNTHESIS; BRAIN GLYCOPROTEINS; NEURITE OUTGROWTH; C-FOS; FOREBRAIN; INCREASES; NCAM;
Keywords:
CHICKEN; GLYCOPROTEINS; CELL ADHESION MOLECULES (NCAM, L1); GLUCOCORTICOIDS; AMNESIA; AVOIDANCE LEARNING; MEMORY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
S.P.R. Rose, "CELL-ADHESION MOLECULES AND THE TRANSITION FROM SHORT-TERM-MEMORY TO LONG-TERM-MEMORY", J PHYSL-PAR, 90(5-6), 1996, pp. 387-391

Abstract

Training chicks on a one-trial passive avoidance task results in a cascade of molecular and cellular processes in two forebrain regions, culminating within 60-90 min in post-translational glycosylation of synaptic membrane proteins and expression of immediate early genes c-fos and c-jun. We have now found a second window of vulnerability of memoryto the protein synthesis inhibitor anisomycin, 4 h downstream of training. By 5.5 h post-training this window closes, to be replaced by a window of sensitivity to blockade of glycoprotein synthesis, presumablyrepresenting post-translational modification of the newly synthesisedproteins. Amongst the pre- and post-synaptic membrane glycoproteins involved at both first and second time windows are the cell adhesion molecules, L1 (at both times) and NCAM (al the later). Molecular dissection of the external membrane domains of L1 distinguishes between a requirement for the IgG domain at the early time, the fibronectin-like domain at the later. The second time window only occurs if the animal istrained on a stimulus strong enough to be remembered for a long period. Weak memories do not persist beyond 6-8 h and the second wave of glycoprotein synthesis does not occur. Thus the second wave may represent the molecular processes required for the alterations in synaptic configuration, by way of the adhesion molecules amongst others, required for the morphological changes in neuronal connectivity hypothesised toencode memory.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:40:40