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Titolo:
CYCLIC-AMP SIGNALING PATHWAY AND CELLULAR PROLIFERATION - INDUCTION OF CREM DURING LIVER-REGENERATION
Autore:
SERVILLO G; PENNA L; FOULKES NS; MAGNI MV; DELLAFAZIA MA; SASSONECORSI P;
Indirizzi:
INST GENET & BIOL MOL & CELLULAIRE,CNRS,INSERM,BP 163 F-67404 ILLKIRCH GRAFFENS FRANCE INST GENET & BIOL MOL & CELLULAIRE,CNRS,INSERM F-67404 ILLKIRCH GRAFFENS FRANCE UNIV PERUGIA,MONTELUCE POLICLIN,INST PATOL GEN I-06100 PERUGIA ITALY
Titolo Testata:
Oncogene
fascicolo: 13, volume: 14, anno: 1997,
pagine: 1601 - 1606
SICI:
0950-9232(1997)14:13<1601:CSPACP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTO-ONCOGENE EXPRESSION; LONG-TERM DESENSITIZATION; GENE-TRANSCRIPTION; TYROSINE AMINOTRANSFERASE; PARTIAL-HEPATECTOMY; GROWTH-FACTOR; RAT-LIVER; BINDING; CAMP; PHOSPHORYLATION;
Keywords:
CAMP; CREM; CREB; LIVER REGENERATION; PROLIFERATION; EARLY RESPONSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
G. Servillo et al., "CYCLIC-AMP SIGNALING PATHWAY AND CELLULAR PROLIFERATION - INDUCTION OF CREM DURING LIVER-REGENERATION", Oncogene, 14(13), 1997, pp. 1601-1606

Abstract

The CREM gene encodes both activators and repressors of cAMP-induced gene expression, An isoform of CREM encodes the powerful transcriptional repressor ICER (Inducible cAMP Early Repressor), which has been shown to be inducible by virtue of an alternative, intronic promoter, TheCREM gene belongs to the early response class and displays a characteristic neuroendocrine cell- and tissue-specific expression, To date ICER inducibility has in non-replicating, terminally differentiated In this paper we document a robust induction of CREM expression in the regenerating rat liver after partial hepatectomy. This represents the first link of inducible CREM expression to the phenomenon of cellular proliferation, Furthermore, it represents the first example of transcriptional activation of a cAMP-responsive factor in the regenerating liver, This has significant physiological relevance since the adenylate cyclase signalling pathway is strongly implicated in liver regeneration, Finally, we show that the repressor ICER is inducible in the hepatoma cell line H35 upon activation of the adenylate cyclase and phosphorylation of the activator CREB.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/10/20 alle ore 00:41:33