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Titolo:
AGE-DEPENDENT AND GENDER-DEPENDENT ASSOCIATION OF THE ANGIOTENSIN-CONVERTING ENZYME GENE WITH ESSENTIAL-HYPERTENSION IN A CHINESE POPULATION
Autore:
CHIANG FT; CHERN TH; LAI ZP; TSENG CD; HSU KL; LO HM; TSENG YZ;
Indirizzi:
NATL TAIWAN UNIV HOSP,DEPT INTERNAL MED,7 CHUNG SHAN S RD TAIPEI 10016 TAIWAN NATL TAIWAN UNIV,COLL MED,DEPT LAB MED TAIPEI 10764 TAIWAN
Titolo Testata:
Journal of human hypertension
fascicolo: 12, volume: 10, anno: 1996,
pagine: 823 - 826
SICI:
0950-9240(1996)10:12<823:AAGAOT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH BLOOD-PRESSURE; DELETION POLYMORPHISM; MYOCARDIAL-INFARCTION; LINKAGE;
Keywords:
ANGIOTENSIN-CONVERTING ENZYME; ELDERLY; POLYMORPHISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
F.T. Chiang et al., "AGE-DEPENDENT AND GENDER-DEPENDENT ASSOCIATION OF THE ANGIOTENSIN-CONVERTING ENZYME GENE WITH ESSENTIAL-HYPERTENSION IN A CHINESE POPULATION", Journal of human hypertension, 10(12), 1996, pp. 823-826

Abstract

A case-control study was carried out on 272 Chinese subjects over 40 years of age, including 157 hypertensives and 115 normotensives, to examine the association between angiotensin-converting enzyme (ACE) geneinsertion/deletion (I/D) polymorphism and blood pressure (BP) status,The I/D polymorphism of the ACE gene was identified by polymerase chain reaction. As a whole group, the difference of allele frequencies between normotensives and hypertensives was statistically significant (chi(2) = 4.46, P=0.03; D/I odds = 1.46), while there was no difference in the genotype distribution (chi(2) = 3.95, P = 0.13). In a subgroup with elderly hypertension (age >65), the frequencies of D-allele and DD genotype significantly increased (chi(2) = 4.43, P = 0.03 and chi(2)= 4.03, P = 0.08, respectively; D/I odds = 2.28), The association andrelative risk increased further in the male gender (chi(2) = 6.65, P = 0.01 and chi(2) = 7.51, P = 0.02 respectively; D/I odds = 4.57 and DD/II odds = 12.00 respectively). The D-allele increased with age in the hypertensives, while the I-allele increased with age in normotensives. Thus, we conclude that the deletion polymorphism of the ACE gene issignificantly associated with male elderly hypertension, at least in this Chinese population, This observation, if proved in a larger population, may have some implications for the prevention and treatment strategy for elderly hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 02:57:23